Usefulness of the Left Anterior Descending Artery Wrapping Around the Left Ventricular Apex to Predict Adverse Clinical Outcomes in Patients With Anterior Wall ST-Segment Elevation Myocardial Infarction (an INFUSE-AMI Substudy)

The American Journal of Cardiology
Nobuaki KobayashiGregg W Stone

Abstract

The relation between left anterior descending coronary artery (LAD) anatomic features and clinical outcomes in patients with anterior ST-segment elevation myocardial infarction has not been fully investigated. The Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction (INFUSE-AMI) trial randomized 452 patients with anterior ST-segment elevation myocardial infarctions who underwent mechanical revascularization to intralesional abciximab versus no abciximab and to manual thrombus aspiration versus no aspiration. The primary end point was infarct size (percentage left ventricular mass) on contrast magnetic resonance imaging at 30 days. "Wraparound LAD" was defined as an LAD reaching the apex and supplying the apical inferior aspect of the heart. Among complete data available in 338 patients, 258 (76.3%) had wraparound LADs. Global infarct size (17.4% vs 16.1%, p = 0.64) and the left ventricular ejection fraction (49.7% vs 48.7%, p = 0.98) by contrast magnetic resonance imaging at 30 days were comparable between patients with and those without wraparound LADs. Regional apical anterior infarct size was comparable (59.5% vs 55.8%, p = 0.559) between the groups; however, apical septal...Continue Reading

References

Feb 1, 1986·Journal of the American College of Cardiology·J S PiroloG W Moore
Mar 1, 1983·Investigative Radiology·L M PerlmuttD C Levin
Mar 18, 2008·The American Journal of the Medical Sciences·Marzenna ZielinskaMichał Tylkowski
Mar 27, 2012·JAMA : the Journal of the American Medical Association·Gregg W StoneUNKNOWN INFUSE-AMI Investigators
Apr 30, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Reuben IliaCarlos Cafri
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee

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Citations

Apr 4, 2017·JACC. Cardiovascular Interventions·Tobias HärleAlbrecht Elsässer
Jun 5, 2020·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Hala Mahfouz BadranGhada Soltan
Sep 26, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Toshiharu FujiiYuji Ikari
Nov 9, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Heerajnarain BulluckDerek J Hausenloy
Jun 29, 2021·JAMA Internal Medicine·Anish KapilSatyavir Yadav

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