Usefulness of the second heart sound for predicting pulmonary hypertension in patients with interstitial lung disease

São Paulo Medical Journal = Revista Paulista De Medicina
Sandra de Barros CobraMarcelo Palmeira Rodrigues

Abstract

P2 hyperphonesis is considered to be a valuable finding in semiological diagnoses of pulmonary hypertension (PH). The aim here was to evaluate the accuracy of the pulmonary component of second heart sounds for predicting PH in patients with interstitial lung disease. Cross-sectional study at the University of Brasilia and Hospital de Base do Distrito Federal. Heart sounds were acquired using an electronic stethoscope and were analyzed using phonocardiography. Clinical signs suggestive of PH, such as second heart sound (S2) in pulmonary area louder than in aortic area; P2 > A2 in pulmonary area and P2 present in mitral area, were compared with Doppler echocardiographic parameters suggestive of PH. Sensitivity (S), specificity (Sp) and positive (LR+) and negative (LR-) likelihood ratios were evaluated. There was no significant correlation between S2 or P2 amplitude and PASP (pulmonary artery systolic pressure) (P = 0.185 and 0.115; P= 0.13 and 0.34, respectively). Higher S2 in pulmonary area than in aortic area, compared with all the criteria suggestive of PH, showed S = 60%, Sp= 22%; LR+ = 0.7; LR- = 1.7; while P2> A2 showed S= 57%, Sp = 39%; LR+ = 0.9; LR- = 1.1; and P2 in mitral area showed: S= 68%, Sp = 41%; LR+ = 1.1; LR- = ...Continue Reading

References

Dec 1, 1976·Circulation Research·H N Sabbah, P D Stein
Feb 1, 1970·American Heart Journal·A Harris
Nov 1, 1968·British Heart Journal·A Harris, G Sutton
Nov 1, 1968·British Heart Journal·G SuttonA Leatham
May 1, 1966·Journal of Applied Physiology·R KusukawaA A Luisada
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·T E KingR M Cherniack
Feb 1, 1955·American Heart Journal·N O FOWLERE P MANNIX
Jun 15, 2004·Journal of the American College of Cardiology·Gerald SimonneauAlfred Fishman
Nov 27, 2004·Clinics in Chest Medicine·Kevin O Leslie
Oct 21, 2005·Chest·Hassan F NadrousJay H Ryu
Aug 4, 2007·Mayo Clinic Proceedings·Jay H RyuEunhee S Yi
Jun 3, 2008·The European Respiratory Journal·J Behr, J H Ryu
Jan 24, 2009·American Journal of Respiratory and Critical Care Medicine·Micah R FisherPaul M Hassoun
Sep 15, 2009·The European Respiratory Journal·N GalièG Simonneau

❮ Previous
Next ❯

Citations

Oct 20, 2020·Expert Review of Respiratory Medicine·Sandra de Barros CobraCésar Augusto Melo-Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.