Usefulness of three-dimensional speckle tracking strain to quantify dyssynchrony and the site of latest mechanical activation.

The American Journal of Cardiology
Hidekazu TanakaJohn Gorcsan

Abstract

Previous methods to quantify dyssynchrony could not determine regional 3-dimensional (3-D) strain. We hypothesized that a novel 3-D speckle tracking strain imaging system can quantify left ventricular (LV) dyssynchrony and site of latest mechanical activation. We studied 64 subjects; 54 patients with heart failure were referred for cardiac resynchronization therapy (CRT) with an ejection fraction 25 +/- 6% and QRS interval 165 +/- 29 ms and 10 healthy volunteer controls. The 3-D speckle tracking system determined radial strain using a 16-segment model from a pyramidal 3-D dataset. Dyssynchrony was quantified as maximal opposing wall delay and SD in time to peak strain. The 3-D analysis was compared to standard 2-dimensional (2-D) strain datasets and site of 3-D latest mechanical activation, not possible by 2D was quantified. As expected, dyssynchrony in patients on CRT was significantly greater than in controls (maximal opposing wall delay 316 +/- 112 vs 59 +/- 12 ms and SD 124 +/- 48 vs 28 +/- 11 ms, p <0.001 vs normal). The 3-D opposing wall delay was closely correlated with 3-D 16-segment SD (r = 0.95) and 2-D mid-LV strain (r = 0.83) and SD (r = 0.85, all p values <0.001). The 3-D site of the latest mechanical activation wa...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Dec 19, 2001·Circulation·C ButterUNKNOWN Pacing Therapy for Chronic Heart Failure II Study Group
Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
Nov 13, 2002·Journal of the American College of Cardiology·Maria Vittoria PitzalisPaolo Rizzon
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Nov 3, 2004·Journal of the American College of Cardiology·Jeroen J BaxMartin J Schalij
Jan 5, 2005·Journal of the American College of Cardiology·Maria Vittoria PitzalisPaolo Rizzon
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
May 27, 2006·The American Journal of Cardiology·Ross T MurphyRichard A Grimm
Sep 4, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Masaaki TakeuchiRoberto M Lang
Oct 9, 2007·Journal of the American College of Cardiology·John GorcsanJeroen J Bax
May 7, 2008·Circulation·Eugene S ChungJaime Murillo
Oct 23, 2008·Journal of the American College of Cardiology·Claudia YpenburgJeroen J Bax
Dec 2, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Masaki TanabeJohn Gorcsan
Mar 21, 2009·Journal of Cardiovascular Electrophysiology·Leslie A SaxonMichael R Bristow

❮ Previous
Next ❯

Citations

Mar 1, 2012·Journal of Cardiovascular Translational Research·Jagdesh KandalaJagmeet P Singh
Mar 20, 2013·Journal of Cardiovascular Translational Research·Daniel R LudwigDavid Schwartzman
Feb 21, 2013·Cardiology in Review·Santanu Biswas, Karthikeyan Ananthasubramaniam
Jan 5, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Kohei YamawakiKen-ichi Hirata
May 18, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·J A van der HeideO Kamp
Aug 2, 2012·The International Journal of Cardiovascular Imaging·Takayuki TsujiKen-ich Hirata
Jan 1, 2012·Current Cardiovascular Imaging Reports·Uyen T TruongDavid J Sahn
Dec 1, 2012·Current Cardiovascular Imaging Reports·John GorcsanTetsuari Onishi
Dec 15, 2010·Heart Failure Reviews·Olusegun A OyenugaJohn Gorcsan
Dec 4, 2010·Journal of the American College of Cardiology·Arthur E Weyman
Jun 4, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hong-kui YuYiu-fai Cheung
Feb 27, 2013·The Canadian Journal of Cardiology·Ian PatersonJames A White
Jan 16, 2016·Journal of Echocardiography·Hidekazu Tanaka, Ken-Ichi Hirata
Oct 16, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kensuke MatsumotoKen-ichi Hirata
Jul 7, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Chattanong YodwutVictor Mor-Avi
Apr 28, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Mariko OkadaKen-ichi Hirata
Jan 12, 2016·Annals of Cardiac Anaesthesia·Vishwas MalikPoonam Malhotra Kapoor
Nov 1, 2011·Revista española de cardiología·John Gorcsan, Hidekazu Tanaka
Sep 29, 2011·Revista española de cardiología·Dominique AugerVictoria Delgado
May 17, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shu-na LiYiu-fai Cheung
Mar 9, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Erwan DonalJ-Claude Daubert
Jul 13, 2012·Echocardiography·Jose A Urbano-MoralNatesa G Pandian
Nov 26, 2015·Cardiac Electrophysiology Clinics·John Gorcsan, Bhupendar Tayal
Jul 15, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Praveen Kerala VarmaFeroze Mahmood
May 25, 2015·Heart Failure Reviews·Massimiliano CantinottiGiorgio Iervasi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.