Usefulness of white blood cell differential for early diagnosis of surgical wound infection following spinal instrumentation surgery

Spine
Jun TakahashiHiroyuki Kato

Abstract

The white blood cell (WBC) count and WBC differential were measured prospectively in patients after spinal instrumentation surgery with or without surgical wound infection. OBJECTIVES.: To investigate the usefulness of WBC differential for early diagnosis of surgical wound infection after spinal instrumentation surgery. Renewed elevation of C-reactive protein (CRP) or WBC, gallium scan, and CRP/transthyretin mass concentration ratio were reported for early diagnosis of surgical wound infection. A total of 39 patients were enrolled in this study: 13 patients who developed wound infection within 2 weeks after spinal instrumentation surgery (infection group) and 26 patients who were comparable with those patients included in the infection group with regard to age, sex, and surgical techniques used (control group). The WBC count and WBC differential were determined before and after surgery. In both groups, WBC and percentage and number of neutrophils showed nearly same change until postoperative 4 days (day 4). However, in the infection group, these parameters had increased after day 4. In both groups, the percentage and number of lymphocytes decreased to 10% or less and 1,000/microL or less on day 1, respectively. These lymphocyte...Continue Reading

References

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Citations

Jan 6, 2012·International Orthopaedics·Antoine GeromettaFabian Bitan
Nov 28, 2012·The Tohoku Journal of Experimental Medicine·Tatsuro SasajiKazuo Iwai
Oct 11, 2011·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Won Ho KimMyung Hee Kim
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Nov 11, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Daisuke KudoYoichi Shimada
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May 18, 2019·Korean journal of anesthesiology·Nethra SurhonneChethana G Mapari
Oct 30, 2020·Acta neurochirurgica·Markus LenskiSebastian Siller
May 6, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideaki ImabayashiKazuhiro Chiba
May 30, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideaki ImabayashiKazuhiro Chiba
Aug 5, 2021·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Hiroaki KijimaYoichi Shimada
Sep 19, 2019·The Journal of Physical Chemistry. B·Andrew H HillDan Fu
Jan 15, 2022·Spinal Cord Series and Cases·Munehisa KoizumiYasuhito Tanaka

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