Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior

AAPS PharmSciTech
Cosima HirschbergMiriam Pein-Hackelbusch

Abstract

There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported. This study utilized 3D printing for rapid prototyping of customized geometries; overall goal was to assess mixing process of powder blends at small-scale with a combination of spectroscopic and mechanical monitoring. As part of the segregation evaluation studies, the flowability of three different paracetamol/filler-blends at different ratios was investigated, inter alia to define the percolation thresholds. Blends with a paracetamol wt% above the percolation threshold were subsequently investigated in relation to their segregation behavior. Rapid prototyping using 3D printing allowed designing two funnels with tailored flow behavior (funnel flow) of model formulations, which could be monitored with an in-line near-infr...Continue Reading

References

Feb 1, 1990·Pharmaceutical Research·D BlattnerH Leuenberger
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J RantanenJ Yliruusi
Aug 16, 2006·Journal of Pharmaceutical and Biomedical Analysis·Weiyong LiGregory D Worosila
Sep 6, 2007·Journal of Pharmaceutical Sciences·Pirjo LuukkonenStaffan Folestad
Jan 10, 2008·AAPS PharmSciTech·Eddy Castellanos GilIsidoro Caraballo
Feb 20, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lizbeth MartínezGabriele Betz
Jun 8, 2013·International Journal of Pharmaceutics·Carl Moritz WagnerJörg Breitkreutz
Jul 9, 2014·International Journal of Pharmaceutics·Benoît IgneCarl A Anderson
Dec 6, 2014·International Journal of Pharmaceutics·Zhonghui HuangRajesh N Davé
Aug 19, 2015·Journal of Pharmaceutical Sciences·Jukka Rantanen, Johannes Khinast

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Citations

Sep 8, 2019·Pharmaceutical Research·Renata Abreu-VillelaIsidoro Caraballo

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Software Mentioned

SIMCA
MATLAB
Comsol Multiphysics
Origin Pro

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