Using a Mixture-of-Bivariate-Regressions Model to Explore Heterogeneity of Effects of the Use of Inhaled Corticosteroids on Gestational Age and Birth Weight Among Pregnant Women With Asthma

American Journal of Epidemiology
Mariia SamoilenkoGeneviève Lefebvre

Abstract

Asthma is a heterogeneous disease, and responses to asthma medications vary noticeably among patients. A substantively oriented objective of this study was to explore the potentially heterogeneous effects of exposure to maternal inhaled corticosteroids (ICS) on gestational age (GA) at delivery and birth weight (BW) using a cohort of 6,197 pregnancies among women with asthma (Quebec, Canada, 1998-2008). A methodologically oriented objective was to comprehensively describe the application of a Bayesian 2-component mixture-of-bivariate-regressions model to address this issue and estimate the effects of ICS on GA and BW jointly. Based on the proposed model, no association between ICS and GA/BW was found for a large proportion of asthmatic pregnancies. However, a positive association between ICS exposure and GA/BW was revealed in a small subset of pregnancies comprising mainly preterm and low-birth-weight infants. A novel application of this model was also subsequently performed using BW z score instead of BW as the outcome variable. In conclusion, the studied mixture-of-bivariate-regressions model was useful for detecting heterogeneity in the effect of ICS on GA and BW in our population of women with asthma. These analyses pave the...Continue Reading

References

Oct 1, 1992·American Journal of Obstetrics and Gynecology·J H PerlowM Porto
Oct 1, 1988·The Journal of Allergy and Clinical Immunology·M SchatzB S Saunders
Oct 6, 1997·The Journal of Allergy and Clinical Immunology·M SchatzD Petitti
Apr 18, 1998·Gastroenterology Clinics of North America·M S Cappell
Aug 3, 2001·Pediatrics·M S KramerUNKNOWN Fetal/Infant Health Study Group of the Canadian Perinatal Surveillance System
Dec 18, 2001·Statistics in Medicine·R W PlattS W Wen
Mar 27, 2002·The Pharmacogenomics Journal·E S SilvermanJ M Drazen
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·Vanessa E MurphyVicki L Clifton
Dec 23, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Stefania TentoniLaura A Zonta
Mar 26, 2004·American Journal of Obstetrics and Gynecology·Mitchell P DombrowskiUNKNOWN National Heart, Lung, and Blood Institute
Jun 23, 2004·The Journal of Allergy and Clinical Immunology·Michael SchatzUNKNOWN National Heart, Lung and Blood Institute
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·UNKNOWN National Heart, Lung, and Blood Institute, UNKNOWN National Asthma Education and Prevention Program Asthma and Pregnancy Working Group
Jan 6, 2007·American Journal of Respiratory and Critical Care Medicine·Stephen C LazarusUNKNOWN National Heart Lung and Blood Institute's Asthma Clinical Research Network
Feb 9, 2007·Lifetime Data Analysis·G A Whitmore, Yi Su
Apr 3, 2007·Molecular Diagnosis & Therapy·John J Lima
Mar 18, 2008·American Journal of Epidemiology·Jennifer A Hutcheon, Robert W Platt
Aug 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Larry Borish, Jeffrey A Culp
May 20, 2009·Pharmacogenomics·Timothy P YorkEdwin J C G van den Oord
Oct 31, 2009·Current Opinion in Pulmonary Medicine·Esther L Langmack, Richard J Martin
Feb 1, 2008·Expert Review of Respiratory Medicine·Ohad Katz, Eyal Sheiner
Jun 25, 2010·Statistics in Medicine·Scott L SchwartzMarie L Miranda
Jul 30, 2010·BMC Pregnancy and Childbirth·Richard CharnigoRussell S Kirby
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Nicolette A HodylVicki L Clifton
Jan 5, 2011·British Journal of Pharmacology·Peter J Barnes
Jun 21, 2011·Immunological Reviews·Carole Ober, Tsung-Chieh Yao
Jul 14, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·V E MurphyP G Gibson
Oct 14, 2011·The New England Journal of Medicine·Kelan G TantisiraScott T Weiss
Oct 14, 2011·The New England Journal of Medicine·Jeffrey M Drazen
Apr 27, 2012·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·M Diane LougheedUNKNOWN Canadian Thoracic Society Asthma Clinical Assembly
May 9, 2012·Midwifery·Lyndsey F WatsonDella Forster
Aug 21, 2012·The European Respiratory Journal·Jennifer A NamazyMichael Schatz
Sep 13, 2012·Pharmacogenomics·Amber Dahlin, Kelan G Tantisira
Oct 31, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A BourdinP Chanez
Jan 31, 2013·The Journal of Allergy and Clinical Immunology·Peter J Barnes
Nov 11, 2014·Expert Opinion on Drug Safety·Jennifer A NamazyMichael Schatz
Dec 3, 2014·Immunology and Allergy Clinics of North America·Michelle Fox Huffaker, Wanda Phipatanakul
Jul 6, 2015·Current Allergy and Asthma Reports·Joshua S DavisKelan G Tantisira
Jul 22, 2015·Expert Opinion on Pharmacotherapy·Jennifer A Namazy, Michael Schatz
Sep 17, 2015·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Luke E Grzeskowiak, Vicki L Clifton
Jan 6, 2016·American Journal of Perinatology·Terry K Morgan
Apr 12, 2016·Breathe·Vanessa E Murphy
Nov 3, 2016·Current Opinion in Pediatrics·Magali Noval RivasMoshe Arditi

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Citations

Jun 12, 2018·Statistics in Medicine·Geneviève LefebvreLucie Blais
Sep 30, 2020·Expert Opinion on Pharmacotherapy·Ruth P Cusack, Gail M Gauvreau

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