Using a monocopper-superoxo complex to prepare multicopper-peroxo species relevant to proposed enzyme intermediates.

Journal of Inorganic Biochemistry
Xinzhe ZhongWilliam B Tolman

Abstract

With the goal of generating a (peroxo)tricopper species analogous to the Peroxy Intermediate proposed for multicopper oxidases, solutions of the copper-superoxide complex [K(Krypt)][LCuO2] (L = N,N'-bis(2,6-diisopropylphenyl)-2,6-pyridinedicarboxamide, Krypt = 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) were reacted with the dicopper(I) complex [(TPBN)Cu2(MeCN)2][PF6]2 at -70 °C (TPBN = N,N,N',N'-tetrakis-(2-pyridylmethyl)-1,4-diaminobutane). A metastable intermediate formed, which on the basis of UV-vis, EPR, and resonance Raman spectroscopy was proposed to derive from reaction of two equivalents of the copper-superoxide with one equivalent of the dicopper(I) complex to yield a complex with two (peroxo)dicopper moieties rather than the desired (peroxo)tricopper PI model. A similar intermediate formed upon reaction of [K(Krypt)][LCuO2] with [(BPMA)Cu(MeCN)][PF6] (BPMA = N,N-bis(2-pyridylmethyl)-methyl-amine), which contained the same donor set as provided by TPBN. Comparison of resonance Raman data and consideration of structural preferences for LCuX species led to hypothesis of a μ-η1:η2-peroxo structure for both intermediates.

References

Nov 7, 1996·Chemical Reviews·Edward I. SolomonTimothy E. Machonkin
Jun 24, 2003·Angewandte Chemie·Takefumi ChishiroYonezo Maeda
Feb 12, 2004·Chemical Reviews·Liviu M MiricaT Daniel P Stack
Feb 12, 2004·Chemical Reviews·Elizabeth A Lewis, William B Tolman
Jul 20, 2004·Inorganic Chemistry·Yoshimitsu TachiShinobu Itoh
Oct 20, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Takao OsakoShinobu Itoh
Jul 24, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Edward I SolomonJungjoo Yoon
Feb 17, 2009·Journal of the American Chemical Society·Heather R LucasKenneth D Karlin
Jun 26, 2009·Journal of the American Chemical Society·Yasuhiro FunahashiHideki Masuda
Oct 10, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Daniel J Kosman
Dec 22, 2009·Chemical Communications : Chem Comm·Ga Young ParkKenneth D Karlin
Oct 28, 2010·Journal of the American Chemical Society·Patrick J DonoghueWilliam B Tolman
Oct 19, 2011·Journal of the American Chemical Society·Patrick J DonoghueWilliam B Tolman
Feb 16, 2012·Inorganic Chemistry·Peter CombaArkadius Waleska
Dec 1, 2011·Journal of Catalysis·Pieter VanelderenBert F Sels
Mar 5, 2014·Chemical Reviews·Edward I SolomonLi Tian
Dec 23, 2014·Angewandte Chemie·Nicole KindermannFranc Meyer
Jan 17, 2015·Journal of the American Chemical Society·Isaac Garcia-BoschKenneth D Karlin
Aug 15, 2015·Journal of Biochemistry·Hirofumi Komori, Yoshiki Higuchi
Dec 7, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·David A QuistKenneth D Karlin
Jan 20, 2017·Chemical Reviews·Courtney E ElwellWilliam B Tolman
Feb 17, 2017·Chemical Reviews·Vincent C-C WangSunney I Chan
Sep 21, 2017·Chemical Reviews·Nicolas Mano, Anne de Poulpiquet
Feb 28, 2018·Metallomics : Integrated Biometal Science·Daniel J Kosman
Aug 8, 2018·Chemical Society Reviews·Elisa BorfecchiaSilvia Bordiga
Sep 12, 2018·Chemistry : a European Journal·Ye-Min ZhaoJin-Gang Liu
May 1, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Sarah E N BrazeauLinda H Doerrer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.