Using a sibling-adoption design to parse genetic and environmental influences on children's body mass index (BMI)

PloS One
Hannah F TavalireLeslie D Leve

Abstract

Dietary and physical activity behaviors formed early in life can increase risk for childhood obesity and have continued negative consequences for lifelong health. Previous research has highlighted the importance of both genetic and environmental (e.g., cultural environment or parental lifestyle) contributions to obesity risk, although these studies typically involve genetically-related individuals residing in the same household, where genetic similarity and rearing environment are inextricably linked. Here we utilize a sibling-adoption design to independently estimate genetic and environmental contributions to obesity risk in childhood and describe how these influences might vary as children age. As part of a prospective adoption study, the current investigation used data from biological siblings reared either apart or together, and nonbiological siblings reared together to estimate the contributions of genetics and environment to body mass indices (BMI) in a large cohort of children (N = 711). We used a variance partitioning model to allocate variation in BMI to that which is due to shared genetics, common environment, or unique environment in this cohort during middle childhood and adolescence. We found 63% of the total varia...Continue Reading

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Citations

Apr 1, 2021·MBio·Hannah F TavalireBrendan J M Bohannan
Aug 4, 2021·Environmental Research·Michael S BloomKelly J Hunt

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Software Mentioned

varComp
R
R package MuMIn
R package lmtest
sjstats
R package gap
R package varComp
lawstat R package

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