Using a Tailored Digital Health Intervention for Family Communication and Cascade Genetic Testing in Swiss and Korean Families With Hereditary Breast and Ovarian Cancer: Protocol for the DIALOGUE Study.

JMIR Research Protocols
Sue KimMaria C Katapodi

Abstract

In hereditary breast and ovarian cancer (HBOC), family communication of genetic test results is essential for cascade genetic screening, that is, identifying and testing blood relatives of known mutation carriers to determine whether they also carry the pathogenic variant, and to propose preventive and clinical management options. However, up to 50% of blood relatives are unaware of relevant genetic information, suggesting that potential benefits of genetic testing are not communicated effectively within family networks. Technology can facilitate communication and genetic education within HBOC families. The aims of this study are to develop the K-CASCADE (Korean-Cancer Predisposition Cascade Genetic Testing) cohort in Korea by expanding an infrastructure developed by the CASCADE (Cancer Predisposition Cascade Genetic Testing) Consortium in Switzerland; develop a digital health intervention to support the communication of cancer predisposition for Swiss and Korean HBOC families, based on linguistic and cultural adaptation of the Family Gene Toolkit; evaluate its efficacy on primary (family communication of genetic results and cascade testing) and secondary (psychological distress, genetic literacy, active coping, and decision ma...Continue Reading

References

Jun 12, 2002·Oncology Nursing Forum·Maria C KatapodiCatherine Waters
Nov 15, 2002·Oncology Nursing Forum·Laurel L NorthouseLaurie Freeman-Gibb
Feb 13, 2003·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Suzanne M Johnson Vickberg
Aug 21, 2003·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Jamie C BrehautDeb Feldman-Stewart
Dec 16, 2003·American Journal of Health Behavior·Matthew W Kreuter, Ricardo J Wray
Mar 16, 2004·Journal of Biomedical Informatics·Andre W Kushniruk, Vimla L Patel
Feb 4, 2005·American Journal of Medical Genetics. Part a·Catharine WangSofia D Merajver
Jan 1, 1997·International Journal of Behavioral Medicine·C S Carver
Mar 20, 2008·Health Education Research·Robert P HawkinsArie Dijkstra
Mar 26, 2009·European Journal of Human Genetics : EJHG·Gillian NycumBartha M Knoppers
Apr 7, 2009·International Journal of Medical Informatics·J M Christian Bastien
May 1, 2009·Oncology Nursing Forum·Maria C KatapodiNoreen C Facione
Aug 17, 2010·CA: a Cancer Journal for Clinicians·Laurel L NorthouseDarlene W Mood
Mar 2, 2012·The New England Journal of Medicine·Michael J Barry, Susan Edgman-Levitan
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Oct 29, 2013·Oncology Nursing Forum·Victoria L ChampionGeorge W Sledge
Mar 22, 2014·Translational Behavioral Medicine·Russell E GlasgowTom Jacobs
Dec 17, 2014·BMC Medical Informatics and Decision Making·Aubri S HoffmanStephen J Bartels
Dec 17, 2014·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Maria Caiata-ZuffereyPierre O Chappuis
Jan 13, 2015·Patient Education and Counseling·Marie-Anne DurandGlyn Elwyn
Apr 13, 2015·Breast Cancer Research and Treatment·Eunyoung KangUNKNOWN Korean Hereditary Breast Cancer Study Group
Jun 4, 2015·JAMA : the Journal of the American Medical Association·Muin J Khoury, James P Evans
Jul 16, 2015·European Journal of Human Genetics : EJHG·Ellen OttenIrene M van Langen
Jul 24, 2015·JAMA : the Journal of the American Medical Association·Steven J KatzMonica Morrow
Sep 9, 2015·Nature Biotechnology·Elizabeth ClainKathryn A Phillips
Jan 28, 2016·Journal of Medical Internet Research·Ania SyrowatkaRobyn Tamblyn
Nov 18, 2016·Medical Anthropology·Nancy J Burke, Holly F Mathews
Dec 18, 2016·Journal of Medical Systems·Irena VrečarBorut Peterlin
Jan 4, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Mary B DalySusan Darlow
Mar 16, 2017·European Journal of Human Genetics : EJHG·Jennefer N KohlerBarbara B Biesecker
Apr 7, 2017·Journal of breast cancer·Eun Hwa ParkUNKNOWN Korean Breast Cancer Society

❮ Previous
Next ❯

Software Mentioned

RE
Family Gene Toolkit
R
CASCADE
DIALOGUE
AIM

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.