Using Actiwatch to monitor circadian rhythm disturbance in Huntington' disease: A cautionary note

Journal of Neuroscience Methods
Jenny TownhillAnne E Rosser

Abstract

Huntington's disease (HD) is an inherited neurodegenerative disorder that is well recognised as producing progressive deterioration of motor function, including dyskinetic movements, as well as deterioration of cognition and ability to carry out activities of daily living. However, individuals with HD commonly suffer from a wide range of additional symptoms, including weight loss and sleep disturbance, possibly due to disruption of circadian rhythmicity. Disrupted circadian rhythms have been reported in mice models of HD and in humans with HD. One way of assessing an individual's circadian rhythmicity in a community setting is to monitor their sleep/wake cycles, and a convenient method for recording periods of wakefulness and sleep is to use accelerometers to discriminate between varied activity levels (including sleep) during daily life. Here we used Actiwatch(®) Activity monitors alongside ambulatory EEG and sleep diaries to record wake/sleep patterns in people with HD and normal volunteers. We report that periods of wakefulness during the night, as detected by activity monitors, agreed poorly with EEG recordings in HD subjects, and unsurprisingly sleep diary findings showed poor agreement with both EEG recordings and activit...Continue Reading

References

Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A Jennifer MortonElizabeth S Maywood
Jan 13, 2006·Journal of Psychopharmacology·Peter GallagherAllan H Young
Jan 24, 2007·Lancet·Francis O Walker
Jul 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patrick N PallierA Jennifer Morton
Feb 19, 2008·Archives of Medical Research·Ana María Estrada SánchezLourdes Massieu
Jan 29, 2009·The Journal of Clinical Endocrinology and Metabolism·N Ahmad AzizRaymund A C Roos
Mar 26, 2009·PloS One·Nadine SalehPatrick Maison
Mar 20, 2010·Parkinsonism & Related Disorders·N Ahmad AzizRaymund A C Roos
Jul 3, 2010·Current Drug Targets·Sofia HultA Petersén
Mar 23, 2012·Sleep Medicine·Michelle A ShortMary A Carskadon
Oct 27, 2012·Experimental Neurology·A Jennifer Morton
Jun 27, 2013·Brain : a Journal of Neurology·Sandor KantorA Jennifer Morton
Aug 29, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Eirini KallioliaThomas T Warner
Aug 1, 2015·Annals of Neurology·Alpar S LazarRoger A Barker

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Citations

Apr 30, 2019·Frontiers in Psychiatry·Radoslawa Herzog-Krzywoszanska, Lukasz Krzywoszanski
Dec 4, 2020·International Journal of Molecular Sciences·Katie AndrewsJinwei Zhang
Jan 26, 2021·Parkinsonism & Related Disorders·Rosanna TortelliEdward J Wild
Feb 9, 2021·Journal of Healthcare Informatics Research·N HernandezW Ben Mortenson

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Methods Mentioned

BETA
transgenic

Software Mentioned

Actiwatch
Genstat

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