Jun 5, 1998

Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia

Schizophrenia Bulletin
N R Swerdlow, Mark A Geyer

Abstract

Certain animal models can greatly enhance our understanding of the neurobiology of schizophrenia and can be used to predict the antipsychotic activity of compounds. Prepulse inhibition (PPI), the reduction in startle produced by a prepulse stimulus, is diminished in schizophrenia patients. Theoretically, deficient PPI in schizophrenia patients is a measure of the loss of sensorimotor gating that may lead to sensory flooding and cognitive fragmentation. In rats, PPI is disrupted by systemic administration of dopamine agonists, serotonin agonists, or glutamate antagonists and by a variety of surgical or pharmacological manipulations of neural circuitry linking the limbic cortex, striatum, pallidum, and pontine reticular formation. This article describes several different ways the loss of PPI in rats can be used as a model for studying the pathophysiology and neurobiology of impaired sensorimotor gating in schizophrenia patients and for predicting antipsychotic activity in novel compounds. First, new experimental strategies may be used to distinguish behavioral profiles of "typical" versus "atypical" antipsychotics. Second, this paradigm can be used to study the effects of early developmental insults--including neonatal lesions an...Continue Reading

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Mentioned in this Paper

Study
Antipsychotic Effect
Limbic System
Proton Pump Inhibitors
Limbic Lobe
Prefrontal Cortex
Globus Pallidus
Abnormal Fragmented Structure
Neostriatum
Genes

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