PMID: 11927265Apr 3, 2002Paper

Using an azobenzene cross-linker to either increase or decrease peptide helix content upon trans-to-cis photoisomerization

Chemistry & Biology
Daniel G FlintG Andrew Woolley

Abstract

Reversible photocontrol of peptide and protein conformation could prove to be a powerful tool for probing function in diverse biological systems. Here, we report reversible photoswitching of the helix content in short peptides containing an azobenzene cross-linker between cysteine residues at positions i, i + 4, or i, i + 11 in the sequence. Trans-to-cis photoisomerization significantly increases the helix content in the i, i + 4 case and significantly decreases the helix content in the i, i + 11 case. These cross-linker designs significantly expand the possibilities for photocontrol of peptide and protein structure.

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S MarquseeR L Baldwin
Jan 1, 1993·Annual Review of Physiology·S R Adams, R Y Tsien
Mar 17, 1997·FEBS Letters·P Pan, H Bayley
May 15, 1998·Neuron·J C MillerH A Lester
Feb 18, 1999·Current Opinion in Chemical Biology·K Curley, D S Lawrence
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·C A RohlR L Baldwin
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J R KumitaG A Woolley
Sep 20, 2001·Journal of the American Chemical Society·C Y HuangF Gai

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Citations

Nov 24, 2004·Nature Neuroscience·Matthew BanghartRichard H Kramer
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Benno SchierlingAlfred Pingoud
Jul 17, 2009·Journal of Biochemistry·Hideki ShishidoShinsaku Maruta
Feb 3, 2005·The Journal of Peptide Research : Official Journal of the American Peptide Society·C RennerL Moroder
Nov 9, 2007·Annual Review of Physical Chemistry·Peter HammJens Bredenbeck
Feb 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jens BredenbeckPeter Hamm
Jun 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Pau GorostizaEhud Y Isacoff
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Janne A IhalainenPeter Hamm
Nov 24, 2011·Protein Science : a Publication of the Protein Society·Arnaldo L SerranoFeng Gai
Jul 3, 2003·Chemistry & Biology·Markus SchüttLuis Moroder
May 15, 2016·Biopolymers·David P Fairlie, Aline Dantas de Araujo
Aug 10, 2004·Chembiochem : a European Journal of Chemical Biology·Chris J WestonRudolf K Allemann
Feb 16, 2016·Physical Chemistry Chemical Physics : PCCP·Cristina García-IriepaMarco Marazzi
Aug 20, 2016·Chemical Communications : Chem Comm·Robert J Mart, Rudolf K Allemann
Mar 30, 2016·Chemical Communications : Chem Comm·Zhilin Yu, Stefan Hecht
Sep 10, 2014·Chemical Society Reviews·Yu Heng LauDavid R Spring
May 31, 2012·Angewandte Chemie·Subhas SamantaG Andrew Woolley
Jun 24, 2011·Chembiochem : a European Journal of Chemical Biology·Subhas Samanta, G Andrew Woolley
Oct 31, 2018·Organic & Biomolecular Chemistry·Mingyan Zhu, Huchen Zhou
Oct 27, 2018·Organic & Biomolecular Chemistry·Alexander V StrizhakDavid R Spring
Sep 21, 2007·Molecular BioSystems·Pau Gorostiza, Ehud Isacoff
Mar 23, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Luis Moroder
Nov 18, 2008·Chembiochem : a European Journal of Chemical Biology·Sabine KneisslRudolf K Allemann
Oct 15, 2009·Journal of Computational Chemistry·K Senthil Kumar, Archita Patnaik
Jun 24, 2010·Angewandte Chemie·Xiaolin WangXiang Zhou
Sep 28, 2005·Chemistry : a European Journal·Máté ErdélyiAdolf Gogoll
Dec 24, 2005·Nature Chemical Biology·Richard H KramerDirk Trauner
Nov 10, 2005·Angewandte Chemie·Lucia GuerreroRudolf K Allemann
Aug 19, 2011·Organic & Biomolecular Chemistry·Xiwen XingXiang Zhou
Dec 8, 2011·Organic & Biomolecular Chemistry·Chi Wi OngHung-Wei Tung
Aug 15, 2019·Chemical Communications : Chem Comm·Lea Albert, Olalla Vázquez
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Oren Tchaicheeyan
Jul 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kevin DayStefano Menegatti
Apr 13, 2011·Chemical Society Reviews·Andrew A Beharry, G Andrew Woolley
Jul 12, 2013·Organic & Biomolecular Chemistry·Ahmed M Ali, G Andrew Woolley
Nov 15, 2018·Micromachines·Lu YangHao Sun
Sep 19, 2006·Soft Matter·Robert J MartRein V Ulijn
Oct 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo Wu, Weiping Zheng
Jan 1, 2012·ISRN Biochemistry·Hang Yin

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