Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies

Bioorganic & Medicinal Chemistry Letters
Nigel GreeneYvonne Will

Abstract

Recent publications have demonstrated that using calculated physiochemical properties can help in the design of compounds that have a decreased risk of significant findings in rodent toxicology studies. In this Letter, we extend this concept and incorporate results from a high throughput cytotoxicity assay to help the drug discovery community select compounds for progression into in vivo studies. The results are presented in an easily interpretable odds ratio so that teams can readily compare compounds and progress potential clinical candidates to the necessary rodent in vivo studies.

References

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Citations

Jul 16, 2011·Journal of Medicinal Chemistry·W Patrick WaltersMark A Murcko
Dec 18, 2013·Chemical Research in Toxicology·Falgun Shah, Nigel Greene
Oct 1, 2011·Nature Reviews. Drug Discovery·Paul D Leeson, Stephen A St-Gallay
Dec 15, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zhiwu Lin, Yvonne Will
Apr 9, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xun ZhangKaren Leach
Sep 3, 2011·Future Medicinal Chemistry·Nigel Greene, Minghu Song
Jul 18, 2012·Future Medicinal Chemistry·Yvonne Will, Thomas Schroeter
Dec 18, 2013·Toxicology and Applied Pharmacology·Franck A AtienzarStéphane Dhalluin
Sep 21, 2012·Expert Opinion on Drug Discovery·John A Arnott, Sonia Lobo Planey
Dec 2, 2015·Chemical Research in Toxicology·Donna M DambachDolores Diaz
Nov 21, 2015·Chemical Research in Toxicology·Eric Blomme, Yvonne Will
Apr 30, 2014·Journal of Applied Toxicology : JAT·Varun Ahuja, Sharad Sharma
Jul 25, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Falgun ShahMichael D Aleo
Oct 23, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E Koslov-DavinoT Schroeter
Jan 18, 2014·Reproductive Toxicology·Jodi M MaglichMathew T Pletcher
Feb 22, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Shuyan LuYvonne Will
Dec 3, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xun ZhangKaren L Leach
Jul 24, 2015·Experimental Biology and Medicine·Lawrence A VernettiD Lansing Taylor
Feb 1, 2012·Molecular Informatics·Xiangyun Wang, Nigel Greene
Mar 16, 2019·Scientific Reports·Mohammad NikbakhtGholamreza Nikbakht Brujeni
Sep 6, 2020·Cell Chemical Biology·Fabien VincentMarie-Claire Peakman

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