Using animal models to improve the design and application of transcranial electrical stimulation in humans

Current Behavioral Neuroscience Reports
Carlos A Sánchez-LeónJavier Márquez-Ruiz

Abstract

Transcranial electrical stimulation (tES) is a non-invasive stimulation technique used for modulating brain function in humans. To help tES reach its full therapeutic potential, it is necessary to address a number of critical gaps in our knowledge. Here, we review studies that have taken advantage of animal models to provide invaluable insight about the basic science behind tES. Animal studies are playing a key role in elucidating the mechanisms implicated in tES, defining safety limits, validating computational models, inspiring new stimulation protocols, enhancing brain function and exploring new therapeutic applications. Animal models provide a wealth of information that can facilitate the successful utilization of tES for clinical interventions in human subjects. To this end, tES experiments in animals should be carefully designed to maximize opportunities for applying discoveries to the treatment of human disease.

References

Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jun 1, 1962·Experimental Neurology·O D CREUTZFELDTH KAPP
Jan 1, 1965·Journal of Neurophysiology·D P PURPURA, J G MCMURTRY
Sep 8, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M A NitscheB-U Meyer
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
Jun 30, 2007·The Journal of Physiology·Jacqueline K DeansJohn G R Jefferys
Jan 22, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Patrick RagertLeonardo G Cohen
May 1, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·David LiebetanzMichael A Nitsche
Jan 16, 2010·Neurobiology of Learning and Memory·John C ChurchwellRaymond P Kesner
Feb 10, 2010·The European Journal of Neuroscience·Marco CambiaghiLetizia Leocani
May 29, 2010·Learning & Memory·Wanda C LeonA Claudio Cuello
Jul 14, 2010·Neuron·Flavio Fröhlich, David A McCormick
Jul 1, 2008·Brain Stimulation·Michael A NitscheAlvaro Pascual-Leone
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simal OzenGyörgy Buzsáki
Aug 9, 2011·Neuropsychological Rehabilitation·Walter Paulus
Oct 5, 2011·Current Opinion in Neurology·Janine Reis, Brita Fritsch
Jan 13, 2012·Journal of Neurophysiology·F RanieriC Grassi
Jan 19, 2012·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Yiyan LiWeiwei Jiang
Feb 7, 2012·Current Biology : CB·Raed A JoundiPeter Brown
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Javier Márquez-RuizJosé María Delgado-García
Aug 11, 2012·Science·Antal BerényiGyörgy Buzsáki
Sep 6, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Giulio RuffiniPedro C Miranda
Sep 8, 2012·Clinical EEG and Neuroscience·Marom BiksonAbhishek Datta
Oct 16, 2012·Brain Research·Lauren Naomi Spezia AdachiIraci L S Torres

❮ Previous
Next ❯

Citations

Dec 17, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marco Baroni
Feb 6, 2021·Scientific Reports·Carlos A Sánchez-LeónJavier Márquez-Ruiz
Oct 3, 2018·Current Opinion in Biomedical Engineering·Carlos A Sánchez-LeónJavier Márquez-Ruiz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Biomedical Engineering
Carlos A Sánchez-LeónJavier Márquez-Ruiz
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Adam J WoodsMichael A Nitsche
Clinical Interventions in Aging
Alice E KaneSusan E Howlett
© 2022 Meta ULC. All rights reserved