Using ante-natal clinic prevalence data to monitor temporal changes in malaria incidence in a humanitarian setting in the Democratic Republic of Congo.

Malaria Journal
Joel HellewellThomas S Churcher

Abstract

The number of clinical cases of malaria is often recorded in resource constrained or conflict settings as a proxy for disease burden. Interpreting case count data in areas of humanitarian need is challenging due to uncertainties in population size caused by security concerns, resource constraints and population movement. Malaria prevalence in women visiting ante-natal care (ANC) clinics has the potential to be an easier and more accurate metric for malaria surveillance that is unbiased by population size if malaria testing is routinely conducted irrespective of symptoms. A suite of distributed lag non-linear models was fitted to clinical incidence time-series data in children under 5 years and ANC prevalence data from health centres run by Médecins Sans Frontières in the Democratic Republic of Congo, which implement routine intermittent screening and treatment alongside intermittent preventative treatment in pregnancy. These statistical models enable the temporal relationship between the two metrics to be disentangled. There was a strong relationship between the ANC prevalence and clinical incidence suggesting that both can be used to describe current malaria endemicity. There was no evidence that ANC prevalence could predict f...Continue Reading

References

Sep 3, 2010·Statistics in Medicine·A GasparriniM G Kenward
Oct 16, 2012·Science·Amy WesolowskiCaroline O Buckee
Dec 4, 2012·Expert Review of Anti-infective Therapy·Michal FriedPatrick E Duffy
Mar 21, 2013·Nature Communications·Patrick G T WalkerAzra C Ghani
Sep 13, 2013·Statistics in Medicine·Antonio Gasparrini
Nov 5, 2014·Malaria Journal·Hugh Jw SturrockRoland D Gosling
Dec 18, 2014·Malaria Journal·Elizabeth A Ashley, Nicholas J White
Aug 25, 2015·The Lancet Global Health·Patrick G T Walker
Dec 30, 2015·ELife·Robert C ReinerDavid L Smith
Aug 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Matthew B Thomas, Andrew F Read
Oct 26, 2016·Population Health Metrics·Elisabeth Zu Erbach-SchoenbergAndrew J Tatem
Jan 31, 2017·Biometrics·Antonio GasparriniMichael G Kenward

❮ Previous
Next ❯

Citations

Nov 23, 2019·Malaria Journal·Nina C BrunnerManuel W Hetzel
Aug 10, 2019·Trends in Parasitology·Alfredo MayorPatrick G T Walker

❮ Previous
Next ❯

Software Mentioned

R
dlnm

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Developing World Bioethics
Willem A Landman, Udo Schüklenk
The British Journal of General Practice : the Journal of the Royal College of General Practitioners
Ha-Neul Seo, Luisa Pettigrew
© 2022 Meta ULC. All rights reserved