Using ApoE Genotyping to Promote Healthy Lifestyles in Finland - Psychological Impacts: Randomized Controlled Trial

Journal of Genetic Counseling
H-L Hietaranta-LuomaAnu Hopia

Abstract

Common health recommendations often incite very little public response, as people instead require individualized information. The purpose of this study was to assess the psychological effects of personal genetic information, provided by different apoE genotypes, as a tool to promote lifestyle changes. This study was a one-year intervention study using healthy adults, aged 20-67 years (n = 107). Their experiences of state anxiety, threat and stage of change were measured three times over a 12 months period. These psychological experiences were assessed, during the genetic information gathering, for three groups: a high-risk group (Ɛ4+, n = 16); a low-risk group (Ɛ4-, n = 35); and a control group (n = 56). The psychological effects of personal genetic risk information were shown to be short-term, although the levels of state anxiety and threat experiences in the high-risk group both remained at a slightly higher level than in the baseline. Threat experiences differed almost significantly (alpha = 0.017) between the Ɛ4+ and Ɛ4- groups (p = 0.034). Information on the apoE genotype impacted the experience of cardiovascular threat; this effect was most intense immediately after genetic feedback was received. However, fears of threat ...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 1, 1997·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·C LermanN Caporaso
Mar 18, 2000·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·M W KreuterB Glassman
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·K Aktan-CollanH Kääriäinen
Nov 22, 2001·Journal of the American Dietetic Association·J Harvey-BerinoE T Poehlman
Oct 12, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B MeiserK Tucker
Jun 7, 2003·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Robert GramlingLarry Culpepper
Oct 16, 2003·JAMA : the Journal of the American Medical Association·Michael Rutter
Mar 11, 2004·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Timothy W SmithC David Jenkins
Jun 25, 2004·American Journal of Medical Genetics. Part a·Theresa MarteauUNKNOWN Genetic Risk Assessment for FH Trial Study Group
Jul 21, 2004·Annals of Internal Medicine·Yiqing SongSimin Liu
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ellen R GritzPatrick M Lynch
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dominick L FroschCaryn Lerman
Jun 17, 2005·Journal of Genetic Counseling·Linda J RomeroRobert L Rhyne
Sep 9, 2005·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Susan K Peterson
Nov 25, 2005·Journal of Geriatric Psychiatry and Neurology·J Scott RobertsUNKNOWN REVEAL (Risk Evaluation and Education for Alzheimer's Disease) Study Group
Mar 6, 2007·Journal of Nutrition Education and Behavior·Marian FitzgibbonAmy L Yaroch
May 1, 2007·The Proceedings of the Nutrition Society·A M MinihaneG Rimbach
Jul 5, 2007·BMC Medical Research Methodology·Rob McCarneyPeter Fisher
Jan 17, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jodi T HeshkaPhilip S Wells
Mar 5, 2008·Alzheimer Disease and Associated Disorders·Serena ChaoRobert C Green
Aug 30, 2008·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·J A Lovegrove, R Gitau
Jul 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Saskia C SandersonColleen M McBride
Jul 17, 2009·The New England Journal of Medicine·Robert C GreenUNKNOWN REVEAL Study Group
Oct 12, 2010·The Cochrane Database of Systematic Reviews·Theresa M MarteauGareth J Hollands
Jan 14, 2011·The New England Journal of Medicine·Cinnamon S BlossEric J Topol
Jan 29, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kurt D ChristensenRobert C Green
Feb 18, 2011·Circulation. Cardiovascular Genetics·Rajani D Aatre, Sharlene M Day
Jul 30, 2011·BMC Public Health·Ruth E CollinsTheresa M Marteau
Feb 7, 2013·Biological Psychology·Evelyn Glotzbach-SchoonAndreas Mühlberger
Apr 18, 2013·International Journal of Environmental Research and Public Health·Sandra CampbellRobyn McDermott
Sep 1, 1971·Journal of Motor Behavior·C D Spielberger

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Citations

Sep 20, 2016·Annals of Physical and Rehabilitation Medicine·Sébastien LacroixAnil Nigam
Apr 21, 2016·Circulation. Cardiovascular Genetics·Jane F FergusonUNKNOWN American Heart Association Council on Functional Genomics and Translational Biology, Council on Epidemiology and Prevention,
Jan 1, 2017·Personalized Medicine·Thierry HurlimannBéatrice Godard
Nov 30, 2019·Public Health Genomics·Suchetana DeKirsi Vähäkangas

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