Using biochemical and isotope geochemistry to understand the environmental and public health implications of lead pollution in the lower Guadiana River, Iberia: a freshwater bivalve study

The Science of the Total Environment
R CompanyM J Bebianno

Abstract

Lead is a natural component of aquatic ecosystems with no known biological role and is highly toxic. Its toxicity stems from its ability to mimic biologically important metals and to produce membrane damage through lipid peroxidation (LPO). Most lead poisoning symptoms are thought to occur by interfering with an essential enzyme, delta-aminolevulinic acid dehydratase (ALAD), the activity of which is markedly inhibited by lead. The purpose of this work was to study the levels and effects of lead pollution (responses of ALAD and oxidative stress biomarker LPO) in the freshwater bivalve Corbicula fluminea along the lower Guadiana River (Portugal and Spain); a major river system impacted by historic mining pollution and more recent anthropogenic inputs. The results show that the enzymatic activity of ALAD is negatively correlated with the total Pb concentration of the whole tissue suggesting that ALAD has considerable potential as a biomarker of lead exposure in C. fluminea. To identify the sources of lead to which bivalves have been exposed, high precision (206)Pb/(204)Pb, (207)Pb/(204)Pb, (208)Pb/(204)/Pb ratios for C. fluminea confirm that historical mining activities in the Iberian Pyrite Belt are the dominant source of lead po...Continue Reading

References

Aug 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Hermes-LimaE J Bechara
Apr 1, 1991·British Journal of Industrial Medicine·E SugawaraY Seki
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Jun 1, 1984·Toxicology Letters· Shafiq-Ur-Rehman
Jul 1, 1994·Archives of Environmental Health·Y S Jiun, L T Hsien
Mar 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·W E Donaldson, S O Knowles
Jun 30, 1998·Trends in Biochemical Sciences·M J WarrenP M Shoolingin-Jordan
Aug 28, 1998·Environmental Research·A J VéronA R Flegal
Nov 21, 2000·Free Radical Biology & Medicine·H Gurer, N Ercal
Jun 28, 2001·American Journal of Epidemiology·S N KeladaM J Khoury
Jan 10, 2002·The Science of the Total Environment·S K TandonV Bihari
Jan 24, 2002·Environmental Toxicology and Chemistry·Sean M StromAndrew S Archuleta
Jul 26, 2002·Environmental Monitoring and Assessment·Christopher J SchmittMike Coffey
Sep 24, 2004·Archives of Environmental Contamination and Toxicology·E Martínez-LópezA J García-Fernández
Jun 8, 2006·Ecotoxicology and Environmental Safety·João Ricardo Maleres Alves CostaCiro Alberto de Oliveira Ribeiro
Jan 6, 2007·Biochemical and Biophysical Research Communications·Tsuyoshi TaharaYasuyoshi Watanabe
Mar 6, 2007·Ecotoxicology and Environmental Safety·Christopher J SchmittDonald E Tillitt
Jun 1, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·O ChampeauJ F Narbonne
May 27, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Wen-Xiong Wang, Philip S Rainbow

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Citations

Sep 23, 2014·Environmental Health and Preventive Medicine·Sunil J Wimalawansa
Jul 20, 2011·Ecotoxicology·Angela SerafimMaria João Bebianno
Oct 17, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Alexandra CravoMaria J Bebianno
Jan 10, 2012·Marine Pollution Bulletin·Jacqueline Krause-NehringSimon R Thorrold
Oct 9, 2013·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Anne M Taylor, William A Maher
Sep 3, 2009·Journal of Environmental Monitoring : JEM·Alexandra CravoMaria João Bebianno

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