Using Blockchain Technology to Manage Clinical Trials Data: A Proof-of-Concept Study

JMIR Medical Informatics
David M MaslovePatrick Martin

Abstract

Blockchain technology is emerging as an innovative tool in data and software security. This study aims to explore the role of blockchain in supporting clinical trials data management and develop a proof-of-concept implementation of a patient-facing and researcher-facing system. Blockchain-based Smart Contracts were built using the Ethereum platform. We described BlockTrial, a system that uses a Web-based interface to allow users to run trials-related Smart Contracts on an Ethereum network. Functions allow patients to grant researchers access to their data and allow researchers to submit queries for data that are stored off chain. As a type of distributed ledger, the system generates a durable and transparent log of these and other transactions. BlockTrial could be used to increase the trustworthiness of data collected during clinical research with benefits to researchers, regulators, and drug companies alike. In addition, the system could empower patients to become more active and fully informed partners in research. Blockchain technology presents an opportunity to address some of the common threats to the integrity of data collected in clinical trials and ensure that the analysis of these data comply with prespecified plans. F...Continue Reading

References

Jan 14, 2005·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·N L Kerr
Feb 18, 2012·JAMA : the Journal of the American Medical Association·Bridget M Kuehn
Apr 18, 2012·Psychological Science·Leslie K JohnDrazen Prelec
Apr 2, 2014·Annals of Internal Medicine·Daniel M HartungMark Helfand
Mar 12, 2015·The New England Journal of Medicine·Monique L AndersonRobert M Califf
Mar 15, 2015·PLoS Biology·Megan L HeadMichael D Jennions
Mar 31, 2017·F1000Research·Timothy NugentMihai Cimpoesu
May 27, 2017·Journal of Biomedical Informatics·Alex RoehrsRodrigo da Rosa Righi
Jul 21, 2017·Trials·Mehdi Benchoufi, Philippe Ravaud
Jul 28, 2017·JMIR MHealth and UHealth·Daisuke IchikawaTaro Ueno
Sep 16, 2017·Circulation. Cardiovascular Quality and Outcomes·Suveen AngraalWade L Schulz
Oct 11, 2017·Journal of the American Medical Informatics Association : JAMIA·Tsung-Ting KuoLucila Ohno-Machado
Dec 20, 2017·F1000Research·Mehdi BenchoufiPhilippe Ravaud
May 5, 2018·Postgraduate Medicine·Juan M Roman-BelmonteE Carlos Rodriguez-Merchan

❮ Previous
Next ❯

Citations

Sep 8, 2020·BMC Medical Research Methodology·Ilhaam A OmarSamer Ellahham
Aug 17, 2020·Journal of Medical Internet Research·MinDong SungYu Rang Park
Aug 16, 2019·Journal of Medical Internet Research·Michael JonesNoah Zimmerman
Sep 1, 2020·Journal of Medical Internet Research·Shuchih Ernest Chang, YiChian Chen
Jul 17, 2020·Journal of Medical Internet Research·Rania El-Gazzar, Karen Stendal
Dec 31, 2020·Sensors·Katarzyna Koptyra, Marek R Ogiela
Nov 20, 2020·Contemporary Clinical Trials·Carmen RosaAimee N C Campbell
Apr 17, 2021·Methods of Information in Medicine·Vinícius Costa LimaRui Pedro Charters Lopes Rijo
Jun 9, 2021·JMIR Medical Informatics·Pedro Elkind VelmovitskyPlinio Pelegrini Morita
Aug 28, 2021·JMIR Medical Informatics·Aldren GonzalesRoger Boodoo

❮ Previous
Next ❯

Software Mentioned

REDCap
Go
Java
Ethereum Virtual Machine
OpenClinica
BlockTrial App
BlockTrial
Ethereum

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Alexander Engel
© 2021 Meta ULC. All rights reserved