Using c-fos as a neural marker of pain

Brain Research Bulletin
J A Harris

Abstract

Just over a decade has past since Hunt et al. reported that the gene c-fos and its protein product Fos are expressed in the spinal cord of rats subjected to peripheral noxious stimulation. These authors showed that noxious stimulation (application of radiant heat or mustard oil) to the hind paw resulted in a massive increase in the expression of Fos in neurons in the dorsal horn of the lumbar spinal cord. Since then, there has been an explosion of studies in which c-fos has been used to study nociception (pain), and the number of such studies increases each year. The net result has been to establish c-fos expression as a valuable tool in pain research. Moreover, recent studies have provided evidence identifying the role of c-fos expression in spinal nociceptive processes. However, there are several important limitations to the practice of using c-fos to study nociception, and these limitations can be easily overlooked as the practice graduates to the status of an established technique. The increasing use of c-fos to study nociception necessitates a critical review of the practice, identifying the shortcomings as well as the strengths of this tool.

References

Mar 1, 1979·The Journal of Comparative Neurology·G J GieslerA I Basbaum
Dec 17, 1976·Brain Research·G J GieslerJ M Besson
Dec 1, 1992·European Journal of Pharmacology·B J ChiassonH A Robertson
Oct 8, 1991·The Journal of Comparative Neurology·E Bullitt
Jan 15, 1990·The Journal of Comparative Neurology·R BursteinG J Giesler
Nov 1, 1989·Trends in Neurosciences·J I Morgan, T Curran
Sep 1, 1989·Journal of Neuroscience Methods·M Dragunow, R Faull
Jul 1, 1989·Brain Research. Molecular Brain Research·G Draisci, M J Iadarola
Feb 20, 1983·The Journal of Comparative Neurology·S B McMahon, P D Wall
Apr 1, 1995·Behavioral Neuroscience·J A HarrisM Bentivoglio
Jan 16, 1995·European Journal of Pharmacology·P HonoréJ M Besson
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·K L WidnellE J Nestler

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Citations

May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Shiro KoizukaFumio Goto
Mar 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hang ZhaoSatoshi Kashimoto
Mar 19, 2005·Die Naturwissenschaften·Pavel NemecHelmut H A Oelschläger
Nov 1, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·C RobertC S Wilson
Sep 29, 2009·Neuroscience Bulletin·Ming-Gang Liu, Jun Chen
Oct 12, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nicoletta Galeotti, Carla Ghelardini
Feb 21, 2004·The Journal of Pain : Official Journal of the American Pain Society·Alvin J BeitzLaura Eikmeier
Sep 12, 2002·European Journal of Pharmacology·Shingo TateyamaToshikazu Nishimori
Feb 11, 2004·Experimental Neurology·Cheng-Shui ZhaoSrinivasa N Raja
Oct 14, 2003·Toxicology and Applied Pharmacology·Zhan-Tao BaiYong-Hua Ji
Aug 26, 2003·Advanced Drug Delivery Reviews·David Borsook, Lino Becerra
Aug 26, 2003·Advanced Drug Delivery Reviews·Anne M WolkaThomas P Davis
May 7, 1999·Brain Research Bulletin·S Fürst
Dec 17, 2003·Behavioral Neuroscience·Justin S RhodesStephen C Gammie
Feb 15, 2002·Cephalalgia : an International Journal of Headache·G J Ter HorstR H Kemper
Oct 17, 2009·Journal of Biomedical Science·Yi-Ruu LinMing-Huan Chan
Mar 10, 2011·Molecular Pain·Ricardo KusudaGuilherme Lucas
Aug 2, 2008·Biological & Pharmaceutical Bulletin·Hye-Jeong HwangDae-Hyun Hahm

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