Using changes in speciation in a dynamic combinatorial library as a fingerprint to differentiate the methylation states of arginine

Chemical Communications : Chem Comm
Alexandria G MullinsMarcey L Waters

Abstract

Herein we describe the development of a sensor array that utilizes the complex response of a dynamic combinatorial library (DCL) to discriminate all of the methylation states of Arg, previously unreported in a sensor array, as well as the methylation states of Lys. We find that the use of all species in the DCL, not just those that bind, allows for discrimination of analytes that are otherwise indistinguishable, demonstrating the value of utilizing a complex network of species for differential sensing.

References

Nov 11, 2005·Angewandte Chemie·Andrey Buryak, Kay Severin
Sep 14, 2006·Chemical Reviews·Peter T CorbettSijbren Otto
Jul 24, 2008·Journal of the American Chemical Society·Kevin R WestSijbren Otto
Nov 26, 2009·Chembiochem : a European Journal of Chemical Biology·Cory S BesharaFraser Hof
Jun 19, 2012·Journal of the American Chemical Society·Samuel A MinakerFraser Hof
Dec 4, 2012·Organic & Biomolecular Chemistry·Mona A Gamal-Eldin, Donal H Macartney
Apr 9, 2013·Journal of the American Chemical Society·Lindsey I JamesMarcey L Waters
Feb 11, 2015·Organic & Biomolecular Chemistry·Anthony P DavisAntonella Dalla Cort
Feb 27, 2015·Chemical Reviews·Lei YouEric V Anslyn
Jan 14, 2016·ACS Chemical Biology·Joshua E Beaver, Marcey L Waters
Jun 17, 2016·Journal of the American Chemical Society·Roberta PinalliEnrico Dalcanale
Jan 7, 2017·Molecular Cell·Roméo S Blanc, Stéphane Richard
Jan 17, 2017·Organic & Biomolecular Chemistry·Thomas HanauerTobias Gruber
May 10, 2017·Chemistry : a European Journal·Angel M ValdivielsoIgnacio Alfonso
Aug 5, 2017·Journal of the American Chemical Society·Yang LiuWenwan Zhong
Feb 21, 2018·Journal of the American Chemical Society·Meagan A BeattyFraser Hof
Apr 13, 2018·Angewandte Chemie·Maria LafuenteIgnacio Alfonso
Apr 20, 2018·Angewandte Chemie·Francesca GuagniniPeter B Crowley
Aug 23, 2018·Chembiochem : a European Journal of Chemical Biology·Tobias Gruber
Feb 21, 2019·Angewandte Chemie·Alexandria G MullinsMarcey L Waters
Jun 25, 2019·Trends in Molecular Medicine·James Jarrold, Clare C Davies

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Citations

Sep 1, 2021·Journal of the American Chemical Society·Emily E HarrisonMarcey L Waters

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