Using Chou's pseudo amino acid composition to predict protein quaternary structure: a sequence-segmented PseAAC approach

Amino Acids
Shao-Wu ZhangQuan Pan

Abstract

In the protein universe, many proteins are composed of two or more polypeptide chains, generally referred to as subunits, which associate through noncovalent interactions and, occasionally, disulfide bonds to form protein quaternary structures. It has long been known that the functions of proteins are closely related to their quaternary structures; some examples include enzymes, hemoglobin, DNA polymerase, and ion channels. However, it is extremely labor-expensive and even impossible to quickly determine the structures of hundreds of thousands of protein sequences solely from experiments. Since the number of protein sequences entering databanks is increasing rapidly, it is highly desirable to develop computational methods for classifying the quaternary structures of proteins from their primary sequences. Since the concept of Chou's pseudo amino acid composition (PseAAC) was introduced, a variety of approaches, such as residue conservation scores, von Neumann entropy, multiscale energy, autocorrelation function, moment descriptors, and cellular automata, have been utilized to formulate the PseAAC for predicting different attributes of proteins. Here, in a different approach, a sequence-segmented PseAAC is introduced to represent...Continue Reading

References

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Citations

Mar 22, 2014·International Journal of Molecular Sciences·Yue-Nong FanKuo-Chen Chou
Feb 26, 2014·International Journal of Molecular Sciences·Shao-Wu ZhangTing-He Zhang
Jan 29, 2014·International Journal of Molecular Sciences·Wang-Ren QiuKuo-Chen Chou
Nov 14, 2012·Journal of Theoretical Biology·Xiwu Yang, Tianming Wang
Nov 17, 2012·Journal of Theoretical Biology·Chenglong YuStephen S-T Yau
Dec 21, 2010·Journal of Theoretical Biology·Kuo-Chen Chou
Nov 15, 2008·Analytical Biochemistry·Hong-Bin Shen, Kuo-Chen Chou
Feb 18, 2011·Journal of Computational Chemistry·Jianxiu GuoGang Wang
Jun 27, 2014·BioMed Research International·Wei ChenKuo-Chen Chou
Jun 21, 2014·Journal of Theoretical Biology·Loris NanniSheryl Brahnam
Sep 10, 2016·BioMed Research International·Chi-Hua TungYen-Wei Chu
Jan 24, 2017·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Shujaat KhanMohammed Bennamoun
Nov 30, 2019·Current Pharmaceutical Design·Kuo-Chen Chou
Nov 22, 2019·Protein and Peptide Letters·Xuan XiaoWang-Ren Qiu
Feb 12, 2010·Molecular Diversity·Xuan XiaoKuo-Chen Chou
Jan 3, 2020·Molecular Genetics and Genomics : MGG·Kuo-Chen Chou

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