Using cumulative toxicity to identify the optimal second-line targeted therapy in patients with metastatic renal cell carcinoma: what's new?

Future Oncology
Giuseppe Di Lorenzo, Sabino De Placido

Abstract

The life expectancy in metastatic renal cell carcinoma patients treated with targeted therapies can be influenced by the time spent on treatment, and the current focus of clinical research in this field appears to be on extending the time on treatment while limiting toxicities. It has been proposed that a strategy based on the sequential administration of two tyrosine kinase inhibitors could result in unacceptable cumulative toxicity for many metastatic renal cell carcinoma patients, while switching to a mTOR inhibitor does not. However, a definite consensus on this issue has not been reached. As very little information from head-to-head studies is available, clinicians have to base their treatment decisions on existing evidence, with an obvious preference for high-quality studies. Some recent studies have provided new insights into the issue of cumulative toxicity of second-line targeted therapies in metastatic renal cell carcinoma patients. In this article, we discuss the evidence emerging from the randomized AXIS and RECORD-3 trials.

References

Feb 16, 2012·British Journal of Cancer·G Di LorenzoC Buonerba
Jun 22, 2012·Expert Review of Anticancer Therapy·Stephan KruckAxel S Merseburger
Dec 21, 2012·Expert Review of Anticancer Therapy·Alessandra FeliciMichele Milella
Mar 5, 2013·Current Opinion in Oncology·Eric A SingerRamaprasad Srinivasan
Apr 17, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John Mendelsohn
Aug 27, 2013·Seminars in Oncology·Bernard Escudier, Martin Gore
Sep 11, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerThomas E Hutson

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