Using "Degree of Extremeness" instead of "Multiples of Median" in first trimester risk assessment for Down syndrome-an improved method or just a gimmick in face of political motivations?

Archives of Gynecology and Obstetrics
P SchmidtAlexander Scharf

Abstract

The concept of first trimester Down syndrome screening based on (NT) nuchal translucency measurement was introduced by the Fetal Medicine Foundation (FMF), London, in the late 1990s. For Germany, the mandate of NT training and auditing was assigned to the newly established German branch of the FMF in 2002. In January 2007, following the organisational split between FMF London and FMF Germany, the FMF Germany released its own, novel calculation software ("Prenatal risk calculation", PRC), for this field. It is the aim of this study to compare the modified biochemical calculation method based on "Degree of Extremeness" (DoE) with the well-proven concept of "Multiple of Median" (MoM). The fbeta-hCG and PAPP-A values of 266 first trimester examinations were categorised by gestational age, nicotine consumption and body weight. For each, a scatter plot and Pearson correlation was derived. As a second step, only patients with no nicotine consumption and a body weight between 55 and 65 kg were considered. The remaining 84 cases were again classified by gestational age and a statistical analysis was performed. The correlation of the DoEs with the respective MoM values was found to be quite good (r = 0.76, P < 0.01). After dividing the p...Continue Reading

References

Feb 1, 1987·American Journal of Obstetrics and Gynecology·G E Palomaki, J E Haddow
May 26, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K SpencerK H Nicolaides
Aug 9, 2002·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·E Merz
Oct 10, 2003·The New England Journal of Medicine·Ronald WapnerUNKNOWN First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group
Jun 21, 2005·Prenatal Diagnosis·Tina SørensenMichael Christiansen
Mar 3, 2007·Archives of Gynecology and Obstetrics·Peter SchmidtAlexander Scharf
May 25, 2007·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Vitaly SchetininAdolfo Hernandez
Jun 23, 2007·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·E Merz

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Citations

Aug 16, 2008·Archives of Gynecology and Obstetrics·Cindy HörmansdörferP Schmidt
Nov 15, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C HörmansdörferP Schmidt

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