Using drug chronotherapy to wean patients from mechanical ventilation

Critical Care Nursing Quarterly
J M ClochesyF E Paschall

Abstract

Discontinuation of positive pressure mechanical ventilation results in decreased intrathoracic pressure. Although there has been extensive research into factors associated with weaning adults from mechanical ventilatory support, little attention has been paid to the role of left ventricular performance. Research also has not focused on interventions that might optimize ventricular performance. The purpose of this article is to explore the potential effect of cardiac dysfunction in weaning and the role of drug chronotherapy as a strategy to modify patients' responses to weaning from mechanical ventilatory support. Biophysical principles involved are reviewed, and the development of a chronotherapeutic intervention is described. Two case examples illustrate the use of drug chronotherapy during the weaning process.

Citations

Mar 22, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Guido R Zanni, Jeannette Y Wick
Sep 24, 2013·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Andreas Liebenhagen, Anna Forsberg
Sep 15, 2010·Pakistan Journal of Biological Sciences : PJBS·E Ilali, Z Taraghi
Jul 25, 1998·Accident and Emergency Nursing·L C Green
May 18, 1999·Heart & Lung : the Journal of Critical Care·S K Frazier
May 27, 2014·Journal of Korean Academy of Nursing·Eun Young Lee, Su Hyun Kim

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