Using electronic health records for population health sciences: a case study to evaluate the associations between changes in left ventricular ejection fraction and the built environment.

JAMIA Open
Yiye ZhangJessica S Ancker

Abstract

Electronic health record (EHR) data linked with address-based metrics using geographic information systems (GIS) are emerging data sources in population health studies. This study examined this approach through a case study on the associations between changes in ejection fraction (EF) and the built environment among heart failure (HF) patients. We identified 1287 HF patients with at least 2 left ventricular EF measurements that are minimally 1 year apart. EHR data were obtained at an academic medical center in New York for patients who visited between 2012 and 2017. Longitudinal clinical information was linked with address-based built environment metrics related to transportation, air quality, land use, and accessibility by GIS. The primary outcome is the increase in the severity of EF categories. Statistical analyses were performed using mixed-effects models, including a subgroup analysis of patients who initially had normal EF measurements. Previously reported effects from the built environment among HF patients were identified. Increased daily nitrogen dioxide concentration was associated with the outcome while controlling for known HF risk factors including sex, comorbidities, and medication usage. In the subgroup analysis,...Continue Reading

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