Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma

Aging
Zibo MengHeshui Wu

Abstract

The tumour microenvironment is one of the significant factors driving the carcinogenesis of Pancreatic adenocarcinoma (PAAD). However, the underlying mechanism of how the tumour microenvironment impacts the prognosis of PAAD is not completely clear. The transcriptome and clinical data of 182 PAAD program cases were downloaded from the TCGA database. Three hundred thirty-three differentially expressed genes (DEGs) between high and low stromal groups and 314 DEGs between high and low immune score groups were identified using ESTIMATE score. Based on the 203 genes differentially expressed simultaneously in two score-related comparisons, we established an 8-mRNA signature to evaluate the prognosis of PAAD patients. Kaplan-Meier curves showed significantly worse survival for patients with high-risk scores in both the training and validation groups. The risk score was an independent prognostic factor and had a high predictive value for the prognosis of patients with PAAD. By searching the TCGA database, we showed that CA9, CXCL9, and GIMAP7 from the 8-mRNA signature were associated with the infiltration levels of immunocytes by regulating FOXO1 expression in PAAD. Unlike traditional methods of screening for differential genes in canc...Continue Reading

References

Feb 28, 1997·Statistics in Medicine·R Tibshirani
Aug 18, 2005·Immunologic Research·David C Linehan, Peter S Goedegebuure
Dec 17, 2008·Molecular Cancer Therapeutics·Yanping WangHyung L Kim
Oct 7, 2009·Nature Reviews. Gastroenterology & Hepatology·Sara RaimondiAlbert B Lowenfels
Oct 12, 2013·Nature Communications·Kosuke YoshiharaRoel G W Verhaak
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Jun 6, 2014·Nature Reviews. Cancer·Gemma K Alderton
Aug 30, 2014·World Journal of Gastroenterology : WJG·Zhihong XuMinoti V Apte
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Vedat Goral
Sep 13, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter HsuRalph Nanan
Oct 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hadi Raeisi ShahrakiNajaf Zare
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Dec 14, 2016·World Journal of Gastroenterology : WJG·Milena Ilic, Irena Ilic
Mar 30, 2017·Journal of Hematology & Oncology·Dagny von AhrensAmit Verma
Sep 13, 2017·Oxidative Medicine and Cellular Longevity·Ghulam MurtazaJianxin Chen
Dec 1, 2017·The Cancer Journal·Linda C ChuElliot K Fishman
Dec 6, 2017·Cancer Treatment Reviews·Ryuma TokunagaHeinz-Josef Lenz
Jan 9, 2018·Seminars in Cancer Biology·Youcai DengJianhua Yu
Jan 23, 2018·Virchows Archiv : an International Journal of Pathology·Kyösti TahkolaIlmo Kellokumpu
Feb 13, 2018·Critical Reviews in Immunology·Adriana Alicia Cabrera-OrtegaDana T Graves
Mar 27, 2018·The Journal of Pathology·Hyeran Helen JeonDana T Graves
Aug 4, 2018·Journal of Cellular Biochemistry·Peng Cheng
Jan 23, 2019·Molecular Cancer·Divya Thomas, Prakash Radhakrishnan
Mar 8, 2019·Virchows Archiv : an International Journal of Pathology·Kyösti TahkolaJan Böhm
Apr 5, 2019·Nature Communications·Yingyao ZhouSumit K Chanda
May 19, 2019·Molecular Genetics & Genomic Medicine·Ke ChenXiujiang Yang
Jul 28, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Penglei GeYang Wu
Sep 20, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yuequn NiuYihua Wu

Related Concepts

Western Blotting
Malignant Neoplasms
Cox Proportional Hazards Models
Gene Expression
Genes
Immunization
Immunohistochemistry
Neoplasms
RNA, Messenger
Forkhead Transcription Factors

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.