Using Functional Connectivity Magnetic Resonance Imaging to Measure Brain Connectivity in Preterm Infants

Nursing Research
Rita PicklerWai Gao

Abstract

The use of functional connectivity magnetic resonance imaging (fcMRI) in research involving preterm infants is relatively new, and its feasibility in this population is not fully established. However, fcMRI images reveal functional neural connections that may be useful in establishing the mechanisms of neuroprotective interventions in preterm infants. The aim of this study was to determine the feasibility of using fcMRI to measure differences in functional neural connections in nursing intervention studies. A pilot study was conducted as part of a longitudinal, randomized controlled trial (RCT) testing the effect of a feeding intervention on neurodevelopmental and clinical outcomes of preterm infants randomly assigned to one of two groups: a patterned feeding experience (PFE) group and a usual feeding care (UFC) group. The fcMRIs were done at term-equivalent age. Visual, motor, and default mode networks were analyzed. Seven infants were studied (four were in the PFE group, and three were in the UFC group). Participants were selected sequentially from the parent RCT. Clear images were obtained from all participants. Differences were noted among PFE and UFC infants: Infants receiving PFE were hyperconnective in the default mode (...Continue Reading

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Citations

Jun 20, 2020·Nursing Research·Rita H PicklerKarin Tepe

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