Using GC Content to Compare Recombination Patterns on the Sex Chromosomes and Autosomes of the Guppy, Poecilia reticulata, and Its Close Outgroup Species.

Molecular Biology and Evolution
Deborah CharlesworthLengxob Yong

Abstract

Genetic and physical mapping of the guppy (Poecilia reticulata) have shown that recombination patterns differ greatly between males and females. Crossover events occur evenly across the chromosomes in females, but in male meiosis they are restricted to the tip furthest from the centromere of each chromosome, creating very high recombination rates per megabase, as in pseudoautosomal regions of mammalian sex chromosomes. We used GC content to indirectly infer recombination patterns on guppy chromosomes, based on evidence that recombination is associated with GC-biased gene conversion, so that genome regions with high recombination rates should be detectable by high GC content. We used intron sequences and third positions of codons to make comparisons between sequences that are matched, as far as possible, and are all probably under weak selection. Almost all guppy chromosomes, including the sex chromosome (LG12), have very high GC values near their assembly ends, suggesting high recombination rates due to strong crossover localization in male meiosis. Our test does not suggest that the guppy XY pair has stronger crossover localization than the autosomes, or than the homologous chromosome in the close relative, the platyfish (Xiph...Continue Reading

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Citations

Aug 6, 2020·G3 : Genes - Genomes - Genetics·Deborah CharlesworthLengxob Yong
Aug 28, 2020·Genome Biology and Evolution·Bonnie A FraserDetlef Weigel
May 22, 2021·Nature Communications·Pablo SalmónCaroline Isaksson
Jul 13, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nicolas Perrin
Aug 10, 2021·PLoS Genetics·Deborah CharlesworthKaren Keegan
Oct 3, 2021·Genome Biology and Evolution·Luis Felipe BenitesGwenaël Piganeau

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