Jan 26, 2016

Using Genome Wide Estimates of Heritability to Examine the Relevance of Gene-Environment Interplay

BioRxiv : the Preprint Server for Biology
Benjamin W Domingue, Jason D Boardman

Abstract

We use genome-wide data from the third generation respondents of the Framingham Heart Study to estimate heritability in body mass index using different quantities of the measured genotype. Heritability decreases rapidly when SNPs implicated by a genome-wide association study are removed but shows essentially no decline when SNPs implicated by a gene-environment interaction in a second genome-wide analysis are removed. This second result is highlighted by our additional finding that the SNPs which explain heritability amongst a subsample defined by higher educational attainment explain no heritability of the heritability in the lower education group, and vice-versa. Finally, we do find consistent heritability estimates when we compare family-based estimates versus those based on measured genotype.

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Mentioned in this Paper

Genome-Wide Association Study
Genome
Gene Products, Protein
Gene-Environment Interaction
Respondents
Body Mass Index Procedure
Body Mass Index
Single Nucleotide Polymorphism
Population Study (Research Activity)
Genotype Determination

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