Using glutamate homeostasis as a target for treating addictive disorders.

Behavioural Pharmacology
Kathryn J Reissner, P W Kalivas

Abstract

Well-developed cellular mechanisms exist to preserve glutamate homeostasis and regulate extrasynaptic glutamate levels. Accumulating evidence indicates that disruptions in glutamate homeostasis are associated with addictive disorders. The disruptions in glutamate concentrations observed after prolonged exposure to drugs of abuse are associated with changes in the function and activity of several key components within the homeostatic control mechanism, including the cystine/glutamate exchanger xc(-) and the glial glutamate transporter, EAAT2/GLT-1. Changes in the balance between synaptic and extrasynaptic glutamate levels in turn influence signaling through presynaptic and postsynaptic glutamate receptors, and thus affect synaptic plasticity and circuit-level activity. In this review, we describe the evidence for impaired glutamate homeostasis as a critical mediator of long-term drug-seeking behaviors, how chronic neuroadaptations in xc(-) and the glutamate transporter, GLT-1, mediate a disruption in glutamate homeostasis, and how targeting these components restores glutamate levels and inhibits drug-seeking behaviors.

References

Oct 1, 1966·Biochemical Pharmacology·A L SheffnerH P Sarett
Nov 1, 1996·The Journal of Biological Chemistry·O HaugetoN C Danbolt
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin
Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
Jul 8, 1999·Current Opinion in Neurobiology·D E BerglesC E Jahr
Nov 24, 1999·Free Radical Biology & Medicine·O W Griffith
Aug 11, 2000·Journal of Neurochemistry·J Cartmell, D D Schoepp
May 23, 2001·Progress in Neurobiology·N C Danbolt
Aug 28, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P Di Ciano, B J Everitt
Sep 13, 2001·The European Journal of Neuroscience·H KatagiriT Manabe
Jul 18, 2002·Trends in Pharmacological Sciences·Gethin J McBean
Aug 15, 2002·Neurochemistry International·Susan G Amara, Andreia C K Fontana
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Zheng-Xiong XiPeter W Kalivas
Oct 29, 2002·Psychopharmacology·Yavin ShahamJane Stewart
Apr 16, 2003·Psychopharmacology·Jonathan L Katz, Stephen T Higgins
Jun 5, 2003·Nature Neuroscience·David A BakerPeter W Kalivas
Oct 8, 2003·Pflügers Archiv : European journal of physiology·Yoshikatsu Kanai, Matthias A Hediger
Jan 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pia BäckströmRainer Spanagel
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·Pia Bäckström, Petri Hyytiä
Aug 6, 2004·Neuron·Karen K SzumlinskiPeter W Kalivas
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer M BossertYavin Shaham
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yosuke MorishimaShigetada Nakanishi
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Roberto I MelendezPeter W Kalivas
Jun 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lina YaoIvan Diamond
Jul 8, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megan M MoranJeremy K Seamans
Aug 2, 2005·The American Journal of Psychiatry·Peter W Kalivas, Nora D Volkow
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pia Bäckström, Petri Hyytiä
Dec 13, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer M BossertYavin Shaham
Jan 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carla Sanchis-SeguraRainer Spanagel
Feb 2, 2006·The American Journal on Addictions·Steven D LaRoweKathleen Brady
Mar 21, 2006·Pharmacology & Therapeutics·Markus Heilig, Mark Egli
May 30, 2006·Nature Neuroscience·Miquel MartinAntonello Bonci
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler

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Citations

Jul 6, 2013·Progress in Neurobiology·Igor ElmanNora D Volkow
Oct 4, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Moonnoh R LeeDoo-Sup Choi
May 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lianne SchmaalAnna E Goudriaan
Nov 21, 2012·Learning & Memory·Juan D Pita-AlmenarArnold Eskin
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wengang WangNigel S Bamford
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kate M WassumNigel T Maidment
Aug 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Saturnino SpigaMarco Diana
Aug 26, 2014·Pharmacological Reports : PR·Krzysztof ŁabuzekBogusław Okopień
Nov 22, 2015·Brain Research Bulletin·Fawaz AlasmariYoussef Sari
Nov 17, 2015·Biomolecules·Tanya MiladinovicGurmit Singh
Oct 27, 2011·Journal of Neuroscience Methods·Kathryn J ReissnerPeter W Kalivas
May 10, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Carlo CavaliereMichele Papa
May 4, 2011·Pharmacology, Biochemistry, and Behavior·M Foster OliveRobert J Malcolm
Mar 16, 2011·Brain, Behavior, and Immunity·F T CrewsLiya Qin
Dec 20, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jenna M SullivanEvan D Morris
Apr 27, 2013·Drug and Alcohol Review·Matthew BrensilverSteven Shoptaw
Sep 20, 2015·Progress in Neurobiology·Alexei VerkhratskyVedrana Montana
Apr 12, 2015·Biological Psychiatry·Michael D ScofieldPeter W Kalivas
Aug 11, 2015·Neuropharmacology·Peter Illes, Alexei Verkhratsky
Jul 21, 2012·The International Journal of Biochemistry & Cell Biology·Anastasia GrafVictoria I Bunik
Aug 20, 2011·The American Journal of Drug and Alcohol Abuse·Stefan G HofmannKathleen M Kantak
Jun 1, 2015·Brain Structure & Function·Grégory GhézaliNathalie Rouach
Feb 23, 2011·Neuron·Marc N PotenzaBruce J Rounsaville
Feb 25, 2015·Physiology & Behavior·Ian C WebbLique M Coolen
Jun 25, 2013·Journal of Psychiatric Research·Emil F CoccaroPaul Vezina

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