Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Wang AnluChen Keji

Abstract

The gut microbiota harvests nutrients from the host while making possible the digestion of complex nutrients and regulating and balancing the immune and metabolic functions. The microbiota itself, and the dysbiosis of the gut flora, are correlated to the onset and progress of diabetes, obesity, and atherosclerosis. Herbal medicine (HM) plays a role in modulating gut microbiota and is widely used in the prevention and treatment of cardiovascular disease (CVD) and its associated conditions, such as diabetes, obesity, and hyperlipidemia. In this review, we focus on the relationship between the microbiota-metabolism-immunity (MMI) axis and CVD (including its risk factors) and the beneficial effects of HM to regulate this crosstalk. The insights may redefine our understanding of how HM works and spark a revolution in HM-based drug discovery.

Citations

Sep 16, 2020·Protein & Cell·Tzu-Lung LinHsin-Chih Lai
Apr 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lin LiZhixi Hu
Jul 11, 2020·Dose-response : a Publication of International Hormesis Society·Mengwei XieShifeng Li
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Wenyi ZhouMingyi Zhao
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Li ShenBairong Shen
Aug 5, 2021·Journal of the Science of Food and Agriculture·Xu SongZhongqiong Yin

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