Using Insulin Infusion Sets in CSII for Longer Than the Recommended Usage Time Leads to a High Risk for Adverse Events: Results From a Prospective Randomized Crossover Study

Journal of Diabetes Science and Technology
Andreas PfütznerDavid Klonoff

Abstract

Infusion sets for use with insulin pumps are recommended for use for 2 to 3 days to avoid local skin reactions, for example, to the insulin formulation and preservatives like meta-cresol. However, many patients use the catheters longer for economic reasons. We performed this study to investigate the tolerability of 2-day use of infusion sets in comparison to 4-day use in a real-world setting. This prospective randomized controlled crossover study with 2 × 3-month observation periods was performed with 24 type 1 patients. At baseline, patients were trained on the use of the infusion system (Medtronic /Mio® or inset™ II) and randomized to any of the 2 treatment sequences. Observation parameters included glycemic control, frequency and nature of device-related, and procedure-related adverse events and patient preference. The per-protocol analysis was performed with 22 patients (5 men, 17 women, age 39 ± 11 years, BMI 27.0 ± 3.5 kg/m2). The number of catheter related adverse events was 290 with 2-day use versus 495 with 4-day use (P < .05). The overall number of treatment related events was 750 with 2-day use versus 934 with 4-day use (P < .001). There was no difference in glycemic control between the treatment arms. Treatment sati...Continue Reading

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Citations

Feb 18, 2016·Diabetes Technology & Therapeutics·Lutz Heinemann
Sep 15, 2016·Expert Opinion on Drug Delivery·Xiaohui Guo, Wei Wang
Dec 20, 2015·Journal of Diabetes Science and Technology·Jean-Luc ArdilouzeJean-Patrice Baillargeon
Feb 10, 2016·Journal of Diabetes Science and Technology·Andreas PfütznerMarco Grenningloh
Feb 3, 2018·Journal of Diabetes Science and Technology·Daniel P HowsmonB Wayne Bequette
Jun 13, 2018·Diabetes Technology & Therapeutics·Anna Korsgaard BergJannet Svensson
Jun 30, 2018·Diabetes Technology & Therapeutics·Lisa BonatoRémi Rabasa-Lhoret
Oct 27, 2018·American Journal of Clinical Dermatology·Patrick M JedlowskiMaryam T Fazel
Apr 2, 2019·Journal of Diabetes Science and Technology·Ershuai Zhang, Zhiqiang Cao
Feb 19, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·P ChoudharyUNKNOWN Diabetes UK
Mar 31, 2017·Journal of Diabetes Science and Technology·David C KlonoffLutz Heinemann
Mar 14, 2020·Diabetes Technology & Therapeutics·Delia WaldenmaierGuido Freckmann
Sep 9, 2020·Journal of Biomedical Materials Research. Part a·Shereen KesserwanUlrike Klueh
Mar 7, 2017·Journal of Diabetes Science and Technology·Anneke GrafDavid N O'Neal
Sep 12, 2018·Clinical Medicine Insights. Endocrinology and Diabetes·Ayman A Al HayekMohamed A Al Dawish
Sep 9, 2016·Journal of Diabetes Science and Technology·Guido FreckmannBettina Petersen
Jan 7, 2021·Annals of Pediatric Endocrinology & Metabolism·Yun Jeong LeeChoong Ho Shin
Sep 26, 2021·Drug Delivery and Translational Research·Shereen KesserwanUlrike Klueh

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