Using Kalman Filtering to Predict Time-Varying Parameters in a Model Predicting Baroreflex Regulation During Head-Up Tilt

IEEE Transactions on Bio-medical Engineering
Brett MatzukaMette S Olufsen

Abstract

The cardiovascular control system is continuously engaged to maintain homeostasis, but it is known to fail in a large cohort of patients suffering from orthostatic intolerance. Numerous clinical studies have been put forward to understand how the system fails, yet noninvasive clinical data are sparse, typical studies only include measurements of heart rate and blood pressure, as a result it is difficult to determine what mechanisms that are impaired. It is known, that blood pressure regulation is mediated by changes in heart rate, vascular resistance, cardiac contractility, and a number of other factors. Given that numerous factors contribute to changing these quantities, it is difficult to devise a physiological model describing how they change in time. One way is to build a model that allows these controlled quantities to change and to compare dynamics between subject groups. To do so, it requires more knowledge of how these quantities change for healthy subjects. This study compares two methods predicting time-varying changes in cardiac contractility and vascular resistance during head-up tilt. Similar to the study by Williams et al. [51], the first method uses piecewise linear splines, while the second uses the ensemble tra...Continue Reading

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Citations

Nov 1, 2018·Biological cybernetics·Nakeya D WilliamsMette S Olufsen
Sep 14, 2018·Biological cybernetics·Maria-Veronica CiocanelMette S Olufsen
Jun 4, 2019·Journal of Mathematical Biology·Nakeya D WilliamsMette S Olufsen
Jan 13, 2017·Journal of the Royal Society, Interface·Sanjay PantIrene E Vignon-Clementel

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