Abstract
The cardiovascular control system is continuously engaged to maintain homeostasis, but it is known to fail in a large cohort of patients suffering from orthostatic intolerance. Numerous clinical studies have been put forward to understand how the system fails, yet noninvasive clinical data are sparse, typical studies only include measurements of heart rate and blood pressure, as a result it is difficult to determine what mechanisms that are impaired. It is known, that blood pressure regulation is mediated by changes in heart rate, vascular resistance, cardiac contractility, and a number of other factors. Given that numerous factors contribute to changing these quantities, it is difficult to devise a physiological model describing how they change in time. One way is to build a model that allows these controlled quantities to change and to compare dynamics between subject groups. To do so, it requires more knowledge of how these quantities change for healthy subjects. This study compares two methods predicting time-varying changes in cardiac contractility and vascular resistance during head-up tilt. Similar to the study by Williams et al. [51], the first method uses piecewise linear splines, while the second uses the ensemble tra...Continue Reading
References
Sep 1, 1991·Clinical Physiology·S MatzenN H Secher
Jan 1, 1994·Circulation·J K Triedman, J P Saul
Jan 1, 1993·Journal of Mathematical Biology·F Kappel, R O Peer
Feb 16, 1996·The Journal of Biological Chemistry·Y LiuN J Holbrook
Jul 15, 1996·The Journal of Physiology·W WielingR L Sprangers
Sep 4, 1999·Statistics in Medicine·L Tierney, A Mira
Feb 14, 2002·Journal of Applied Physiology·Thomas HeldtRoger G Mark
Jul 31, 2002·The Journal of Clinical Hypertension·Thomas G Pickering
Feb 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Mauro Ursino, Elisa Magosso
May 7, 2003·Journal of Theoretical Biology·J T Ottesen, M Danielsen
Sep 5, 2003·Experimental Physiology·Mark P M HarmsNiels H Secher
Aug 6, 2004·Bulletin of Mathematical Biology·D M Bortz, P W Nelson
Apr 30, 2005·Journal of Applied Physiology·Mette S OlufsenVera Novak
Sep 9, 2005·Acta Anaesthesiologica Scandinavica·J J van LieshoutN H Secher
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Jun 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mette S OlufsenVera Novak
Mar 11, 2008·Investigative Ophthalmology & Visual Science·Clare E GilbertUNKNOWN Refractive Error Study in Children Study Group
Jul 19, 2008·Journal of Applied Physiology·Jan T GroothuisMaria T E Hopman
Mar 19, 2009·Mathematical Biosciences and Engineering : MBE·Scott R PopeMette S Olufsen
Apr 1, 2010·Physiological Genomics·Scott M BugenhagenDaniel A Beard
Sep 1, 2004·Environmental Health and Preventive Medicine·Kazunari EnishiReizo Mita
Jul 26, 2011·SIAM Review·Hongyu MiaoHulin Wu
May 17, 2012·Journal of Mathematical Biology·Mette S Olufsen, Johnny T Ottesen
Aug 14, 2012·Mathematical Biosciences and Engineering : MBE·Alex CapaldiAlun L Lloyd
Aug 21, 2013·Mathematical Medicine and Biology : a Journal of the IMA·Nakeya D WilliamsMette S Olufsen
Dec 19, 2013·PLoS Computational Biology·Adam MahdiMette S Olufsen
Citations
Nov 1, 2018·Biological cybernetics·Nakeya D WilliamsMette S Olufsen
Sep 14, 2018·Biological cybernetics·Maria-Veronica CiocanelMette S Olufsen
Jun 4, 2019·Journal of Mathematical Biology·Nakeya D WilliamsMette S Olufsen
Jan 13, 2017·Journal of the Royal Society, Interface·Sanjay PantIrene E Vignon-Clementel
Apr 30, 2021·Frontiers in Physiology·Bao LiYoujun Liu