Using Machine Learning-Based Multianalyte Delta Checks to Detect Wrong Blood in Tube Errors

American Journal of Clinical Pathology
Matthew W Rosenbaum, Jason M Baron

Abstract

An unfortunate reality of laboratory medicine is that blood specimens collected from one patient occasionally get mislabeled with identifiers from a different patient, resulting in so-called "wrong blood in tube" (WBIT) errors and potential patient harm. Here, we sought to develop a machine learning-based, multianalyte delta check algorithm to detect WBIT errors and mitigate patient harm. We simulated WBIT errors within sets of routine inpatient chemistry test results to develop, train, and evaluate five machine learning-based WBIT detection algorithms. The best-performing WBIT detection algorithm we developed was based on a support vector machine and incorporated changes in test results between consecutive collections across 11 analytes. This algorithm achieved an area under the curve of 0.97 and considerably outperformed traditional single-analyte delta checks. Machine learning-based multianalyte delta checks may offer a practical strategy to identify WBIT errors prior to test reporting and improve patient safety.

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Citations

Nov 18, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Rui Zhen TanTze Ping Loh
Jan 1, 2020·American Journal of Clinical Pathology·Rui Zhen TanTze Ping Loh
Mar 18, 2020·Critical Reviews in Clinical Laboratory Sciences·Deirdre L Church, Christopher Naugler
May 6, 2020·American Journal of Clinical Pathology·Robert C Benirschke, Thomas J Gniadek
Sep 2, 2020·Clinical Chemistry·Edmund H WilkesRachel S Carling
Jan 14, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Shukang HeZhiguo Wang
Jul 25, 2020·JMIR Medical Informatics·Avishek Choudhury, Onur Asan
Oct 13, 2020·Critical Reviews in Clinical Laboratory Sciences·Sander De BruyneJoris R Delanghe
Dec 2, 2020·Journal of the American Medical Informatics Association : JAMIA·Jason M BaronMatthew Prime
Jun 13, 2021·Journal of Clinical Pathology·Rivak PunchooNelishia Pillay
Jul 3, 2021·Annals of Clinical Biochemistry·Christopher-John Farrell
Aug 12, 2021·The Journal of Applied Laboratory Medicine·Shannon Haymond, Christopher McCudden
Sep 25, 2021·Clinical Chemistry·Daniel S HermanThomas J S Durant
Oct 31, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Christopher-John L Farrell

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