Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health.

Molecular Psychiatry
Jessica O'LoughlinJessica Tyrrell

Abstract

Late diurnal preference has been linked to poorer mental health outcomes, but the understanding of the causal role of diurnal preference on mental health and wellbeing is currently limited. Late diurnal preference is often associated with circadian misalignment (a mismatch between the timing of the endogenous circadian system and behavioural rhythms), so that evening people live more frequently against their internal clock. This study aims to quantify the causal contribution of diurnal preference on mental health outcomes, including anxiety, depression and general wellbeing and test the hypothesis that more misaligned individuals have poorer mental health and wellbeing using an actigraphy-based measure of circadian misalignment. Multiple Mendelian Randomisation (MR) approaches were used to test causal pathways between diurnal preference and seven well-validated mental health and wellbeing outcomes in up to 451,025 individuals. In addition, observational analyses tested the association between a novel, objective measure of behavioural misalignment (Composite Phase Deviation, CPD) and seven mental health and wellbeing outcomes. Using genetic instruments identified in the largest GWAS for diurnal preference, we provide robust evid...Continue Reading

References

Feb 6, 2003·Journal of Biological Rhythms·Till RoennebergMartha Merrow
Jun 1, 2005·Physiology & Behavior·Thomas A WillisLawrence Smith
May 12, 2006·Chronobiology International·Marc WittmannTill Roenneberg
Sep 18, 2007·Sleep Medicine·Sarah P Megdal, Eva S Schernhammer
Sep 20, 2008·Nature Reviews. Genetics·Joseph S TakahashiErin L McDearmon
Jan 14, 2009·Genetic Epidemiology·Rui Xiao, Michael Boehnke
Jan 4, 2013·Chronobiology International·Ilona MerikantoTimo Partonen
Apr 23, 2013·Journal of Biological Rhythms·Myriam JudaTill Roenneberg
Oct 26, 2013·International Journal of Epidemiology·Marie-Jo A BrionPeter M Visscher
Jan 15, 2014·Chronobiology International·Hanna KonttinenAri Haukkala
May 16, 2014·Chronobiology International·Shingo KitamuraKazuo Mishima
Jun 4, 2014·International Review of Psychiatry·Kelly Glazer Baron, Kathryn J Reid
Oct 28, 2014·Chronobiology International·Rosemary ToomeyMichael J Lyons
Nov 29, 2014·Journal of Sleep Research·Mikhail F BorisenkovOlga N Kasyanova
Jan 21, 2015·Journal of Internal Medicine·C Dibner, U Schibler
Mar 17, 2015·Current Biology : CB·Céline VetterTill Roenneberg
May 6, 2016·Chronobiology International·Fabio FabbianRoberto Manfredini
May 25, 2016·Current Biology : CB·Till Roenneberg, Martha Merrow
Sep 22, 2016·International Journal of Epidemiology·Jack BowdenGeorge Davey Smith
Oct 21, 2016·Endocrine Reviews·Gregory D M PotterLaura J Hardie
Dec 9, 2016·Scientific Reports·Dorothee FischerTill Roenneberg
Apr 2, 2017·Sleep·David A KalmbachPhilip R Gehrman
Apr 4, 2017·Journal of Biological Rhythms·Krithika SwaminathanAndrew J K Phillips
May 21, 2017·European Journal of Epidemiology·Stephen Burgess, Simon G Thompson
Oct 24, 2017·Current Sleep Medicine Reports·Stephen M JamesHans P A Van Dongen
Jun 12, 2018·Current Sleep Medicine Reports·Liia KiveläNiki Antypa
Jul 14, 2018·BMJ : British Medical Journal·Neil M DaviesGeorge Davey Smith
Jul 25, 2018·European Journal of Epidemiology·Stephen Burgess, Jeremy A Labrecque
Oct 12, 2018·Nature·Clare BycroftJonathan Marchini
Nov 8, 2018·The European Journal of Neuroscience·Céline Vetter
Nov 14, 2018·International Journal of Epidemiology·Jessica TyrrellElina Hyppönen
Apr 11, 2019·BMJ : British Medical Journal·Brooke LevisUNKNOWN DEPRESsion Screening Data (DEPRESSD) Collaboration
Jul 3, 2019·International Journal of Epidemiology·Mark J AdamsAndrew M McIntosh
Jul 25, 2019·Biology·Till RoennebergEva C Winnebeck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.