Using Mesenchymal Stromal Cells in Islet Transplantation

Stem Cells Translational Medicine
Ahmed A ArzouniPeter M Jones

Abstract

Islet transplantation has the potential to cure type 1 diabetes, but current clinical transplantation protocols are inefficient because of the extensive loss of functional islets during the immediate post-transplantation period. Studies in rodent models have demonstrated that co-transplanting mesencyhmal stromal cells (MSCs) with islets improves graft functional survival and transplantation outcomes, and some of the beneficial effects of MSCs are attributable to bioactive molecules secreted by MSCs. Clinical islet transplantation is almost exclusively via the hepatic portal vein, which does not facilitate co-engraftment of islets and MSCs, so attention is currently focused on using cell-free cocktails of MSC-derived products to treat islets prior to transplantation. This approach has the potential to overcome many of the technical and regulatory hurdles associated with using MSCs as an adjuvant therapy for human islet transplantation. Stem Cells Translational Medicine 2018;7:559-563.

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Citations

May 9, 2019·Stem Cells Translational Medicine·Ahmed A ArzouniPeter M Jones
Sep 11, 2020·Tissue Engineering. Part B, Reviews·Rachel E GurlinEsther Latres
Apr 19, 2020·Stem Cell Research & Therapy·Orianne VillardAnne Wojtusciszyn
Jun 27, 2020·World Journal of Gastroenterology : WJG·Irina V ArutyunyanGennady T Sukhikh
Jan 28, 2020·Xenotransplantation·Adwin ThomasChristopher Burlak
Feb 6, 2021·Stem Cells Translational Medicine·Ella L HubberPeter M Jones
Feb 15, 2021·Trends in Neurosciences·Dipankar DuttaSteven M Jay
Jan 6, 2021·Tissue Engineering. Part B, Reviews·Rei KuwabaraPaul de Vos
Feb 14, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Christoph SchröderThomas Linn
Oct 7, 2021·Stem Cell Reviews and Reports·Fanny LebretonEkaterine Berishvili

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