Using meta-regression analyses in addition to conventional systematic review methods to examine the variation in cost-effectiveness results - a case study

BMC Health Services Research
Laura T BurgersW K Redekop

Abstract

Systematic reviews of cost-effectiveness analyses summarize results and describe study characteristics. Variability in the study results is often explained qualitatively or based on sensitivity analyses of individual studies. However, variability due to input parameters and study characteristics (e.g., funding or study quality) is often not statistically explained. As a case study, a systematic review on the cost-effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS) using meta-regression analyses is performed to explore the usefulness of such methods compared with conventional review methods. We attempted to identify and review all modelling studies published until January 2012 that compared costs and consequences of DES versus BMS. We extracted general study information (e.g., funding), modelling methods, values of input parameters, and quality of the model using the Philips et al. checklist. Associations between study characteristics and the incremental costs and effectiveness of individual analyses were explored using regression analyses corrected for study ID. Sixteen eligible studies were identified, with a combined total of 508 analyses. The overall quality of the models was moderate (59% ± 15%). This ...Continue Reading

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Citations

Apr 13, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Olena Lena MandrikJeremy D Goldhaber-Fiebert

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SPSS

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