Using Modern Neuroscience to Inform Opioid Use and Abuse Liability in Adolescents

Orthopaedic Nursing
T Celeste Napier, Amanda L Persons

Abstract

Opioid abuse and overdosing have reached epidemic status in the United States, and this epidemic has profound negative effects on the lives of adolescents and their families. A combination of readily available opioids (including illicit opioids, such as heroin, and overprescribed prescription opioid-based painkillers) and an abuse vulnerability inherent to adolescence drives the problem. The pharmacology of opioids in the context of adolescent brain neurobiology helps explain the enhanced vulnerability to drug abuse experienced by the young. This report overviews these topics as they relate to orthopaedic procedures employed for adolescent patients.

References

May 2, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hamish M MunroFrances A Farley
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nitin GogtayPaul M Thompson
May 27, 2004·The Journal of the American Academy of Orthopaedic Surgeons·Laurence E Dahners, Brian H Mullis
Oct 8, 2005·The American Journal of Sports Medicine·David B CohenScott A Rodeo
Nov 6, 2008·JAMA : the Journal of the American Medical Association·George E WoodyPaul Fudala
Aug 20, 2010·Developmental Neuropsychology·Anna C K van DuijvenvoordeHilde M Huizenga
Nov 15, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Philip VelizCarol J Boyd
Jan 31, 2014·The American Journal of Sports Medicine·Emily R DodwellStephen Lyman
Nov 5, 2014·Psychological Bulletin·Ivy N DefoeMarcel A G van Aken
May 20, 2015·Journal of Pediatric Orthopedics·Brian C WernerFrank Winston Gwathmey
Oct 28, 2015·Pediatrics·Richard MiechKennon Heard
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Deborah DowellRoger Chou
Mar 16, 2016·JAMA : the Journal of the American Medical Association·James A BakerBrian T Bateman
Aug 1, 2016·The Lancet. Psychiatry·George F Koob, Nora D Volkow
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Emma J KilfordSarah-Jayne Blakemore
Dec 7, 2016·The Journal of Pain : Official Journal of the American Pain Society·Catherine E CallinanMichael A Ashburn
May 5, 2017·Substance Use & Misuse·J Deanna WilsonMarc Fishman
Aug 3, 2017·JAMA Surgery·Mark C BicketChristopher L Wu
Sep 20, 2017·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Stacy L ReynoldsMichael S Runyon
Oct 12, 2017·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Naveen PoonaiDebra Bartley
Dec 1, 2017·Anesthesia and Analgesia·Constance L MonittoMyron Yaster
Feb 8, 2018·Journal of Athletic Training·Philip von RosenAnders Kottorp
Mar 6, 2018·The Clinical Journal of Pain·Mark D Sullivan

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