Using molecular profiles to tailor treatment in breast cancer: are they ready for prime time?

Current Opinion in Obstetrics & Gynecology
Florentia Peintinger

Abstract

In this article, recent developments with molecular profiling in breast cancer and future directions will be highlighted. Gene-expression profiling revealed four major biologic subtypes that reflect intertumoral heterogeneity of breast cancer and have led to the development of prognostic tools to facilitate adequate treatment in early breast cancer. A number of commercially available prognostic tests have been introduced for implementation in clinical routine. Also, predictive tools and approaches to characterize molecular portraits of metastatic breast cancer in order to overcome treatment resistance have been investigated. Efforts to identify the quantity and quality of clonal selection and genomic variability through modern genomic profiling led successfully to new insights into targeted treatment with more effective drugs and the promise to overcome resistance. Multigene approaches and novel microarray platforms such as the next-generation sequencing technology are feasible in clinical practice in order to assess the prognosis more precisely and to identify new molecular targets for developing more effective drugs in the near future.

References

Aug 30, 2000·Nature·C M PerouD Botstein
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rachel SchiffC Kent Osborne
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew Arnold, Alexandros Papanikolaou
Feb 16, 2006·Journal of the National Cancer Institute·Christos SotiriouMauro Delorenzi
May 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Soonmyung PaikNorman Wolmark
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel S ParkerPhilip S Bernard
Aug 1, 2009·Nature Reviews. Drug Discovery·Pixu LiuJean J Zhao
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Anindita ChakrabartyCarlos L Arteaga
Mar 21, 2012·The Journal of Experimental Medicine·Dai HoriuchiAndrei Goga
Mar 24, 2012·Cancer Cell·Douglas Hanahan, Lisa M Coussens
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Oct 5, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P DubskyUNKNOWN Austrian Breast and Colorectal Cancer Study Group (ABCSG)
Apr 10, 2013·Genome Research·Daniel E NewburgerArend Sidow
Jul 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitch DowsettJack Cuzick
Sep 21, 2013·Nature·Philippe L BedardLillian L Siu

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Citations

Feb 19, 2015·Metabolites·Ayesha N Shajahan-HaqRobert Clarke

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