Using mouse cranial muscles to investigate neuromuscular pathology in vivo

Neuromuscular Disorders : NMD
Lyndsay M MurraySimon H Parson

Abstract

Neuromuscular pathology is a classic hallmark of many diseases such as muscular dystrophy, myasthenia gravis, amyotrophic lateral sclerosis and spinal muscular atrophy. It is also a feature of many congenital and acquired myopathies and neuropathies such as diabetic neuropathy and toxin-exposure. The availability of experimentally accessible nerve-muscle preparations from rodent models in which pathological events can be studied in nerve and muscle, as well as at the neuromuscular junction, is therefore of fundamental importance for investigating neuromuscular disease. The group of small cranial muscles, which move the ear in the mouse provide ideal experimental preparations for the study of neuromuscular disease in vivo, but information regarding their anatomical and functional characteristics is currently lacking. Here, we provide a detailed description of the levator auris longus, auricularis superior, abductor auris longus and interscutularis muscles. In addition, we briefly review their differential fibre type and developmental characteristics, which can be exploited to aid our understanding of neuromuscular vulnerability and to provide preferable alternatives to more traditional muscle preparations such as gastrocnemius, ...Continue Reading

References

Mar 1, 1961·Brain : a Journal of Neurology·V MACDERMOT
Aug 6, 2005·The Journal of Comparative Neurology·Anneliese M SchaeferJeff W Lichtman
Mar 6, 2007·Neurobiology of Disease·Noor RamjiDouglas W Zochodne
Feb 13, 2009·PLoS Biology·Ju LuJeff W Lichtman
Nov 4, 2009·Human Molecular Genetics·Lyndsay M MurrayThomas H Gillingwater
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rocío RuizLucía Tabares

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Citations

Aug 16, 2011·Human Molecular Genetics·Chantal A MutsaersThomas H Gillingwater
Feb 18, 2014·Journal of Neuroscience Methods·James N SleighM Zameel Cader
Aug 7, 2018·The Journal of Comparative Neurology·Nuria García-MagroCarlos Avendaño
Jan 14, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lyndsay M MurraySimon H Parson
Dec 15, 2020·Journal of Neuroscience Methods·Wen-Yo TuChengyong Shen
Jun 12, 2021·Scientific Reports·Alan Mejia MazaCarole H Sudre

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