Using Multilevel Mixtures to Evaluate Intervention Effects in Group Randomized Trials

Multivariate Behavioral Research
M Lee Van HornRichard F Catalano

Abstract

There is evidence to suggest that the effects of behavioral interventions may be limited to specific types of individuals, but methods for evaluating such outcomes have not been fully developed. This study proposes the use of finite mixture models to evaluate whether interventions, and, specifically, group randomized trials, impact participants with certain characteristics or levels of problem behaviors. This study uses latent classes defined by clustering of individuals based on the targeted behaviors and illustrates the model by testing whether a preventive intervention aimed at reducing problem behaviors affects experimental users of illicit substances differently than problematic substance users or those individuals engaged in more serious problem behaviors. An illustrative example is used to demonstrate the identification of latent classes, specification of random effects in a multilevel mixture model, independent validation of latent classes, and the estimation of power for the proposed models to detect intervention effects. This study proposes specific steps for the estimation of multilevel mixture models and their power and suggests that this model can be applied more broadly to understand the effectiveness of intervent...Continue Reading

References

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Citations

Apr 28, 2010·Prevention Science : the Official Journal of the Society for Prevention Research·Sabrina OesterleRichard F Catalano
Jul 4, 2012·Structural Equation Modeling : a Multidisciplinary Journal·M Lee Van HornGeorge Howe
Nov 9, 2010·Structural Equation Modeling : a Multidisciplinary Journal·Kimberly L Henry, Bengt Muthén
Jun 9, 2016·Structural Equation Modeling : a Multidisciplinary Journal·M Lee Van HornThomas Jaki
Feb 16, 2013·Prevention Science : the Official Journal of the Society for Prevention Research·Sabrina OesterleRichard F Catalano
Jul 6, 2014·American Journal of Preventive Medicine·M Lee Van HornSabrina Oesterle
Feb 1, 2015·Journal of School Psychology·Michael A Lawson, Katherine E Masyn
Apr 4, 2013·American Journal of Epidemiology·Artemis KoukounariChristl A Donnelly
Oct 1, 2018·Educational and Psychological Measurement·Jungkyu Park, Hsiu-Ting Yu
Jan 1, 2017·Structural Equation Modeling : a Multidisciplinary Journal·Saebom JeonHwan Chung

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