Using multiple imputation to assign pesticide use for non-responders in the follow-up questionnaire in the Agricultural Health Study.

Journal of Exposure Science & Environmental Epidemiology
Sonya L HeltsheLaura E Beane Freeman

Abstract

The Agricultural Health Study (AHS), a large prospective cohort, was designed to elucidate associations between pesticide use and other agricultural exposures and health outcomes. The cohort includes 57,310 pesticide applicators who were enrolled between 1993 and 1997 in Iowa and North Carolina. A follow-up questionnaire administered 5 years later was completed by 36,342 (63%) of the original participants. Missing pesticide use information from participants who did not complete the second questionnaire impedes both long-term pesticide exposure estimation and statistical inference of risk for health outcomes. Logistic regression and stratified sampling were used to impute key variables related to the use of specific pesticides for 20,968 applicators who did not complete the second questionnaire. To assess the imputation procedure, a 20% random sample of participants was withheld for comparison. The observed and imputed prevalence of any pesticide use in the holdout dataset were 85.7% and 85.3%, respectively. The distribution of prevalence and days/year of use for specific pesticides were similar across observed and imputed in the holdout sample. When appropriately implemented, multiple imputation can reduce bias and increase pre...Continue Reading

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Citations

Apr 25, 2012·Cancer Causes & Control : CCC·Kathryn Hughes BarryMichael C R Alavanja
Nov 23, 2012·American Journal of Epidemiology·Stella KoutrosMichael C R Alavanja
Jun 3, 2015·International Journal of Cancer. Journal International Du Cancer·Sharon R SilverLaura E Beane Freeman
Mar 25, 2016·Occupational and Environmental Medicine·Maartje BrouwerHans Kromhout
Sep 22, 2017·Environmental Health Perspectives·Lawrence S EngelLaura E Beane Freeman
Jul 8, 2016·Environmental Health Perspectives·Matthew R BonnerMichael C R Alavanja
Feb 23, 2018·Journal of the National Cancer Institute·Catherine C LerroLaura E Beane Freeman
Oct 22, 2015·Journal of Exposure Science & Environmental Epidemiology·Tom Cole-HunterMark Nieuwenhuijsen
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May 2, 2020·International Journal of Epidemiology·Catherine C LerroLaura E Beane Freeman
Nov 15, 2017·Journal of the National Cancer Institute·Gabriella AndreottiLaura E Beane Freeman
Jan 1, 2019·Journal of the National Cancer Institute·Lianne Sheppard, Rachel M Shaffer
Sep 29, 2015·International Journal of Epidemiology·Stella KoutrosLaura E Beane Freeman
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Jul 22, 2020·Environmental Health Perspectives·Gabriella AndreottiJonathan N Hofmann
Oct 25, 2020·Occupational and Environmental Medicine·Srishti ShresthaDale P Sandler

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