Using parametric regressors to disentangle properties of multi-feature processes.

Behavioral and Brain Functions : BBF
Guilherme WoodKlaus Willmes

Abstract

FMRI data observed under a given experimental condition may be decomposed into two parts: the average effect and the deviation of single replications from this average effect. The average effect is represented by the mean activation over a specific condition. The deviation from this average effect may be decomposed into two components as well: systematic variation due to known empirical factors and pure measurement error. In most fMRI designs deviations from mean activation may be treated as measurement error. Nevertheless, often deviation from the average also may contain systematic variation that can be distinguished from simple measurement error. In these cases, the average fMRI signal may provide only a coarse picture of real brain activation. The larger the variation within-condition, the coarser the average effect and the more relevant is the impact of deviations from it. Systematic deviation from the mean activation may be examined by defining a set of parametric regressors. Here, the applicability of parametric methods to refine the evaluation of fMRI studies is discussed with special emphasis on (i) examination of the impact of continuous predictors on the fMRI signal, (ii) control for variation within each experiment...Continue Reading

Citations

Dec 20, 2011·Cerebral Cortex·Wiebke TrostPatrik Vuilleumier
Dec 7, 2013·Human Brain Mapping·Marcus RothkirchPhilipp Sterzer
Jan 30, 2014·NeuroImage·Sarah BaumeisterDaniel Brandeis
Mar 12, 2015·Frontiers in Systems Neuroscience·David M ArnoldussenAlbert V van Den Berg
Aug 1, 2016·The Journal of the Acoustical Society of America·Sophie MeekingsSophie K Scott
Aug 7, 2019·Cephalalgia : an International Journal of Headache·Maike MöllerArne May

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