Using Patient-Derived Induced Pluripotent Stem Cells to Model and Treat Epilepsies

Current Neurology and Neuroscience Reports
Xixi Du, Jack M Parent

Abstract

Human induced pluripotent stem cells (iPSCs) are transforming the fields of disease modeling and precision therapy. For the treatment of neurological disorders, iPSCs introduce the possibility for targeted cell-based therapies by deriving patient-specific neural tissue in vitro that may ultimately be used for transplantation. We review iPSC technologies and their applications that have already advanced our understanding of neurological disorders, focusing on the epilepsies. We also discuss the application of powerful new tools such as genome editing and multi-well, multi-electrode array recording platforms to iPSC disease modeling and therapy development for the epilepsies. Despite some limitations, the field of iPSCs is evolving rapidly and is quickly becoming vital for understanding mechanisms of genetic epilepsies and for future patient-specific therapeutic applications.

References

Aug 10, 2002·Circulation Research·Kenneth R BohelerAnna M Wobus
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ikuo OgiwaraKazuhiro Yamakawa
Aug 22, 2009·Nature Protocols·Bao-Yang Hu, Su-Chun Zhang
Oct 17, 2009·Nature Protocols·Bao-Yang HuSu-Chun Zhang
Oct 20, 2009·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Noemi FusakiMamoru Hasegawa
Apr 3, 2010·Nature Protocols·Gabsang LeeLorenz Studer
Aug 24, 2010·Cell Stem Cell·Jason TchieuKathrin Plath
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stormy J ChamberlainMarc Lalande
Jun 4, 2011·Journal of the American Society of Nephrology : JASN·Ting ZhouMiguel A Esteban
Jun 15, 2011·Cell·Ricardo Dolmetsch, Daniel H Geschwind
Jul 9, 2011·Lancet·Simon Shorvon, Torbjorn Tomson
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kun-Yong KimIn-Hyun Park
Aug 11, 2011·Human Molecular Genetics·Maria C MarchettoFred H Gage
Nov 29, 2011·Nature Medicine·Sergiu P PaşcaRicardo E Dolmetsch
Mar 21, 2012·Journal of Molecular Cell Biology·Ori Bar-NurNissim Benvenisty
Mar 27, 2012·Cell Stem Cell·Marc ThierFrank Edenhofer
May 9, 2012·Cell Stem Cell·Shila MekhoubadKevin Eggan
May 30, 2012·Human Molecular Genetics·Jing LiuPaul J Hagerman
Jun 26, 2012·Nature Biotechnology·Ethan S LippmannEric V Shusta
Jan 5, 2013·Nature Protocols·Laura MenendezStephen Dalton
May 4, 2013·Molecular Brain·Norimichi HigurashiShinichi Hirose

❮ Previous
Next ❯

Citations

Jun 25, 2019·Epilepsy Currents·Helen E Scharfman
Aug 24, 2017·Cell and Tissue Research·Drew M ThodesonJenny Hsieh
Jul 30, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anuradha YadavRajnish Kumar Chaturvedi
Aug 8, 2019·Stem Cells and Development·Luke C DuttonDavid J Connolly
Jun 17, 2020·Pharmacological Reviews·Wolfgang LöscherAnnamaria Vezzani
Feb 17, 2019·Theoretical Medicine and Bioethics·Mary Jean WalkerKatrina Hutchison
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Dinesh UpadhyaAshok K Shetty
Nov 17, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Phoebe McCrorieRuman Rahman
Jul 3, 2021·Journal of Clinical Medicine·Rossella BorghiClaudia Compagnucci
Oct 14, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Caren Armstrong, Eric D Marsh

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.