Using PEGylated magnetic nanoparticles to describe the EPR effect in tumor for predicting therapeutic efficacy of micelle drugs

Nanoscale
Ling ChenYu Zhang

Abstract

Micelle drugs based on a polymeric platform offer great advantages over liposomal drugs for tumor treatment. Although nearly all of the nanomedicines approved in the clinical use can passively target to the tumor tissues on the basis of an enhanced permeability and retention (EPR) effect, the nanodrugs have shown heterogenous responses in the patients. This phenomenon may be traced back to the EPR effect of tumor, which is extremely variable in the individuals from extensive studies. Nevertheless, there is a lack of experimental data describing the EPR effect and predicting its impact on therapeutic efficacy of nanoagents. Herein, we developed 32 nm magnetic iron oxide nanoparticles (MION) as a T2-weighted contrast agent to describe the EPR effect of each tumor by in vivo magnetic resonance imaging (MRI). The MION were synthesized by a thermal decomposition method and modified with DSPE-PEG2000 for biological applications. The PEGylated MION (Fe3O4@PEG) exhibited high r2 of 571 mM-1 s-1 and saturation magnetization (Ms) of 94 emu g-1 Fe as well as long stability and favorable biocompatibility through the in vitro studies. The enhancement intensities of the tumor tissue from the MR images were quantitatively measured as TNR (Tum...Continue Reading

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Citations

May 26, 2018·Nanotechnology·Yimin WangShuQi Wang
Jan 5, 2019·Journal of Biomaterials Science. Polymer Edition·Longyi PiaoJing Jiang
Jul 5, 2019·Drug Development and Industrial Pharmacy·Xin-Cheng ZhongJian-Qing Gao
Feb 11, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Shihao Li, Lin Zhang
May 19, 2019·International Journal of Molecular Sciences·Le XueJianfei Sun
May 12, 2020·Journal of Biomaterials Applications·Zhiheng GuoZhenpeng Wang
Jul 3, 2020·ACS Applied Materials & Interfaces·Sangmin JeonKwangmeyung Kim
Apr 8, 2019·ACS Biomaterials Science & Engineering·Beibei ZhangChunshui Yu

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