Using post-bronchodilator FEV₁ is better than pre-bronchodilator FEV₁ in evaluation of COPD severity

COPD
Chiung-Zuei ChenTzuen-Ren Hsiue

Abstract

The current standards for the diagnosis and treatment of patients with COPD clearly rely on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria based on post-bronchodilator spirometric values. However, clinical evidence for using the post-bronchodilator FEV₁ in the severity classification has not been fully investigated. Patients with COPD were enrolled and followed up prospectively between October 2006 and January 2011. We compared the observed 3-year risk of all causes and respiratory mortality with the risk predicted by the pre- and post-bronchodilator percent predicted FEV₁. Other important phenotypes including BMI, MMRC dyspnea scale, ECOG performance status and severe AECOPD (acute exacerbation) were also compared between the two groups. The different severity classifications of COPD, measured according the GOLD guidelines by post- and pre-bronchodilator percent predicted FEV₁ were compared for prediction of mortality. There were 35 deaths among the 300 COPD patients (11.7%). Multivariate analysis showed that the post-bronchodilator percent predicted FEV₁ was a significant independent predictor of mortality but pre-bronchodilator percent predicted FEV₁ was not (p = 0.008 vs 0.126) and it was more st...Continue Reading

References

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Citations

Feb 14, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chiung-Zuei ChenTzuen-Ren Hsiue
Aug 13, 2014·Genetic Epidemiology·Margaret M ParkerUNKNOWN COPDGene Investigators
Jun 17, 2014·Respiratory Medicine·José M MarínMarc Miravitlles
Oct 27, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Aleksander Grande HansenHeidi Beate Eggesbø
Feb 14, 2018·The European Respiratory Journal·Tang-Hsiu HuangChiung-Zuei Chen
Jul 25, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Laxmi BhattaBen M Brumpton
Sep 10, 2020·Respiratory Medicine·Chiung-Zuei ChenJung-Der Wang

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