Using Predicted Cardiovascular Disease Risk in Conjunction With Blood Pressure to Guide Antihypertensive Medication Treatment

Journal of the American College of Cardiology
Paul Muntner, Paul K Whelton

Abstract

Using cardiovascular disease (CVD) risk instead of or in addition to blood pressure (BP) to guide antihypertensive treatment is an active area of research. The purpose of this review is to provide an overview of studies that could inform this treatment paradigm. We review data from randomized trials on relative and absolute CVD risk reduction that can occur when antihypertensive treatment is guided by CVD risk. We also review population-level data on using CVD risk in conjunction with BP to guide antihypertensive treatment, the broad distribution in CVD risk for people with similar BP levels, and the use of CVD risk for guiding antihypertensive treatment among subgroups including older adults, young adults, and those with diabetes mellitus or chronic kidney disease. In addition, we review potential challenges in implementing antihypertensive treatment recommendations that incorporate CVD risk. In closing, we provide recommendations for using CVD risk in combination with BP to guide antihypertensive treatment.

Citations

Mar 23, 2018·Nature Reviews. Disease Primers·Suzanne OparilPaul K Whelton
Apr 7, 2018·Korean Circulation Journal·Martin G Myers
Jul 14, 2018·Expert Review of Clinical Pharmacology·Ashish CorreaWilbert S Aronow
Feb 23, 2018·Stroke; a Journal of Cerebral Circulation·Daniel T LacklandPhilip B Gorelick
Mar 29, 2019·Circulation Research·Yuqing ZhangLisheng Liu
Feb 1, 2020·The Journal of Clinical Hypertension·Paul K WheltonXin-Hua Zhang
Feb 9, 2018·Cardiology in Review·Wilbert S Aronow, William H Frishman
Feb 19, 2020·Expert Review of Cardiovascular Therapy·Wilbert S Aronow
Dec 4, 2019·VASA. Zeitschrift für Gefässkrankheiten·Ulrich FrankPiotr Terlecki
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May 14, 2020·Journal of Human Hypertension·Richard L WeinbergRobert D Brook
Mar 15, 2018·Drugs·Wilbert S Aronow, William H Frishman
May 26, 2018·Diabetologia·Christoph NowakJohan Ärnlöv
May 7, 2019·Annals of Internal Medicine·James Brian Byrd, Robert D Brook
Jul 30, 2017·Current Hypertension Reports·Wilbert S Aronow
Jun 21, 2020·Current Problems in Cardiology·Abdul WahabHani Jneid
May 1, 2020·American Journal of Preventive Cardiology·Wilbert S Aronow
Nov 18, 2018·Urologic Oncology·Nicholas Russell, Mathis Grossmann

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