Using primary teeth and archived dried spots for exposomic studies in children: Exploring new paths in the environmental epidemiology of pediatric cancer.

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Philip J LupoMichael E Scheurer

Abstract

It is estimated that 300,000 children 0-14 years of age are diagnosed with cancer worldwide each year. While the absolute risk of cancer in children is low, it is the leading cause of death due to disease in children in high-income countries. In spite of this, the etiologies of pediatric cancer are largely unknown. Environmental exposures have long been thought to play an etiologic role. However, to date, there are few well-established environmental risk factors for pediatric malignancies, likely due to technical barriers in collecting biological samples prospectively in pediatric populations for direct measurements. In this review, we propose the use of novel or underutilized biospecimens (dried blood spots and teeth) and molecular approaches for exposure assessment (epigenetics, metabolomics, and somatic mutational profiles). Future epidemiologic studies of pediatric cancer should incorporate novel exposure assessment methodologies, data on molecular features of tumors, and a more complete assessment of gene-environment interactions.

References

Mar 29, 1979·The New England Journal of Medicine·H L NeedlemanP Barrett
Oct 13, 2006·The New England Journal of Medicine·Kevin C OeffingerUNKNOWN Childhood Cancer Survivor Study
Apr 7, 2007·Pediatric Research·Dana C DolinoyRandy L Jirtle
Apr 10, 2008·Journal of Exposure Science & Environmental Epidemiology·Sanwat N ChaudhuriUNKNOWN Rocky Mountain Biomonitoring Consortium
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·William E FunkStephen M Rappaport
Nov 26, 2009·Analytica Chimica Acta·Kayoko KatoAntonia M Calafat
Dec 14, 2011·Maternal and Child Health Journal·Natalie P ArcherJohn F Villanacci
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·Gary J PattiGary Siuzdak
Jan 15, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·William E FunkAndrew J Ghio
Feb 21, 2013·Molecular Genetics and Metabolism·Mads Vilhelm HollegaardDavid Michael Hougaard
Feb 23, 2013·Current Opinion in Pediatrics·Manish Arora, Christine Austin
Jul 23, 2013·Epidemiology·Natalie S ShenkerPaolo Vineis
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Dec 19, 2013·PloS One·Stefano TizianiGiovanni Paternostro
Feb 12, 2014·Alcoholism, Clinical and Experimental Research·Ludmila N BakhirevaWilliam F Rayburn
Mar 25, 2014·Current Opinion in Genetics & Development·Ludmil B Alexandrov, Michael R Stratton
May 14, 2014·Pediatrics·Logan G SpectorAnne M Joseph
Feb 10, 2016·Current Opinion in Pediatrics·Syam S AndraManish Arora
Apr 5, 2016·American Journal of Human Genetics·Bonnie R JoubertStephanie J London
May 6, 2016·Cold Spring Harbor Molecular Case Studies·Clary B Clish
Jun 4, 2016·Environmental Health Perspectives·Kristine K DennisGary W Miller
Jun 17, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·A ModabberniaA Reichenberg
Jun 22, 2016·Environmental Health Perspectives·Sarah E ReeseStephanie J London
Jul 15, 2016·International Journal of Environmental Research and Public Health·Jessica W NelsonRuby H N Nguyen
Jul 23, 2016·Environmental Health Perspectives·Olena GruzievaErik Melén
Nov 5, 2016·Science·Ludmil B AlexandrovMichael R Stratton
Nov 16, 2016·Molecular Psychiatry·C LiuD Levy
Oct 25, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S J van DijkP L Molloy
Dec 24, 2017·Placenta·Samantha L Wilson, Wendy P Robinson
Jan 28, 2018·Human Genomics·Nicholas J W RattrayCaroline H Johnson
Feb 28, 2018·Mass Spectrometry Reviews·Liang CuiYie Hou Lee
Mar 1, 2018·Nature·Susanne N GröbnerStefan M Pfister

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