Using R and WinBUGS to fit a generalized partial credit model for developing and evaluating patient-reported outcomes assessments.

Statistics in Medicine
Yuelin Li, Ray Baser

Abstract

The US Food and Drug Administration recently announced the final guidelines on the development and validation of patient-reported outcomes (PROs) assessments in drug labeling and clinical trials. This guidance paper may boost the demand for new PRO survey questionnaires. Henceforth, biostatisticians may encounter psychometric methods more frequently, particularly item response theory (IRT) models to guide the shortening of a PRO assessment instrument. This article aims to provide an introduction on the theory and practical analytic skills in fitting a generalized partial credit model (GPCM) in IRT. GPCM theory is explained first, with special attention to a clearer exposition of the formal mathematics than what is typically available in the psychometric literature. Then, a worked example is presented, using self-reported responses taken from the international personality item pool. The worked example contains step-by-step guides on using the statistical languages r and WinBUGS in fitting the GPCM. Finally, the Fisher information function of the GPCM model is derived and used to evaluate, as an illustrative example, the usefulness of assessment items by their information contents. This article aims to encourage biostatisticians ...Continue Reading

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Citations

Mar 26, 2013·Biometrical Journal. Biometrische Zeitschrift·Tiago M Fragoso, Mariana Cúri
May 20, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Yuelin LiTim A Ahles
May 28, 2016·BMC Medical Research Methodology·N Maritza DowlingChenxi Li
Dec 7, 2016·Western Journal of Nursing Research·Marjorie BottByron Gajewski
Feb 10, 2018·Multivariate Behavioral Research·Yuelin LiRebecca Loeb
Nov 22, 2015·Behavior Genetics·Inga SchwabeStéphanie M van den Berg
Mar 13, 2014·Conservation Biology : the Journal of the Society for Conservation Biology·Doug P ArmstrongYvan Richard
Aug 1, 2015·Educational and Psychological Measurement·Allison J Ames, Kelli Samonte
Feb 15, 2019·BJPsych Open·Andrea SinesiHelen Cheyne

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