Using regional homogeneity to reveal altered spontaneous activity in patients with mild cognitive impairment

BioMed Research International
Yumei WangXueyi Wang

Abstract

Most patients with mild cognitive impairment (MCI) are thought to be in an early stage of Alzheimer's disease (AD). Resting-state functional magnetic resonance imaging reflects spontaneous brain activity and/or the endogenous/background neurophysiological process of the human brain. Regional homogeneity (ReHo) rapidly maps regional brain activity across the whole brain. In the present study, we used the ReHo index to explore whole brain spontaneous activity pattern in MCI. Our results showed that MCI subjects displayed an increased ReHo index in the paracentral lobe, precuneus, and postcentral and a decreased ReHo index in the medial temporal gyrus and hippocampus. Impairments in the medial temporal gyrus and hippocampus may serve as important markers distinguishing MCI from healthy aging. Moreover, the increased ReHo index observed in the postcentral and paracentral lobes might indicate compensation for the cognitive function losses in individuals with MCI.

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Citations

Jan 1, 2018·European Journal of Hospital Pharmacy. Science and Practice·Jing Li, Zhiping Li
Apr 26, 2018·Frontiers in Aging Neuroscience·Zhuqing LongHongwen Chen
Nov 30, 2019·Frontiers in Neural Circuits·Zhigang QiJie Lu

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